Precision chemical heating for diagnostic devices

Decoupling nucleic acid amplification assays from infrastructure requirements such as grid electricity is critical for providing effective diagnosis and treatment at the point of care in low-resource settings. Here, we outline a complete strategy for the design of electricity-free precision heaters...

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Bibliographic Details
Published in:Lab on a chip 2015-12, Vol.15 (23), p.4423-4432
Main Authors: Buser, J R, Diesburg, S, Singleton, J, Guelig, D, Bishop, J D, Zentner, C, Burton, R, LaBarre, P, Yager, P, Weigl, B H
Format: Article
Language:English
Subjects:
Alternative energy sources
Amplification
Decoupling
Devices
Diagnostic Techniques and Procedures - instrumentation
Electric Power Supplies
Equipment Design
Heaters
Heating
Medical services
Nucleic Acid Amplification Techniques - instrumentation
Nucleic acids
Point-of-Care Systems
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Summary:Decoupling nucleic acid amplification assays from infrastructure requirements such as grid electricity is critical for providing effective diagnosis and treatment at the point of care in low-resource settings. Here, we outline a complete strategy for the design of electricity-free precision heaters compatible with medical diagnostic applications requiring isothermal conditions, including nucleic acid amplification and lysis. Low-cost, highly energy dense components with better end-of-life disposal options than conventional batteries are proposed as an alternative to conventional heating methods to satisfy the unique needs of point of care use.
ISSN:1473-0197
1473-0189
DOI:10.1039/c5lc01053e