Restrictive cardiomyopathy caused by chloroquine

A 59 year old white woman who had been treated with chloroquine phosphate for 25 years presented with signs of congestive heart failure and was diagnosed as having restrictive cardiomyopathy by non-invasive methods. Electron microscopy of a biopsy specimen of skeletal muscle showed lesions compatibl...

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Bibliographic Details
Published in:British Heart Journal 1993-05, Vol.69 (5), p.451-452
Main Authors: Iglesias Cubero, G, Rodriguez Reguero, J J, Rojo Ortega, J M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiomyopathy, Restrictive - chemically induced
Cardiomyopathy, Restrictive - pathology
Chloroquine - adverse effects
Drug toxicity and drugs side effects treatment
Female
Humans
Medical sciences
Middle Aged
Muscles - ultrastructure
Myocardium - ultrastructure
Pharmacology. Drug treatments
Time Factors
Toxicity: cardiovascular system
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Description
Summary:A 59 year old white woman who had been treated with chloroquine phosphate for 25 years presented with signs of congestive heart failure and was diagnosed as having restrictive cardiomyopathy by non-invasive methods. Electron microscopy of a biopsy specimen of skeletal muscle showed lesions compatible with chloroquine myopathy. The patient died five weeks after presentation. Electron microscopy of heart tissue showed similar lesions to those of the skeletal muscle.
ISSN:0007-0769
1355-6037
1468-201X
2053-5864
DOI:10.1136/hrt.69.5.451