The Anti-Acne Potential and Chemical Composition of Knautia drymeia Heuff. and Knautia macedonica Griseb Extracts

The treatment of acne and other seborrheic diseases has arisen as a significant clinical challenge due to the increasing appearance of multi-drug resistant pathogens and a high frequency of recurrent lesions. Taking into consideration the fact that some species are valuable curatives in skin disease...

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Published in:International journal of molecular sciences 2023-05, Vol.24 (11), p.9188
Main Authors: Chrząszcz, Małgorzata, Miazga-Karska, Małgorzata, Klimek, Katarzyna, Dybowski, Michał P, Typek, Rafał, Tchórzewska, Dorota, Dos Santos Szewczyk, Katarzyna
Format: Article
Language:English
Subjects:
Acne
Androgens
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biocompatibility
Biomedical materials
Chemical composition
Cyclooxygenase-1
Cyclooxygenase-2
Cytotoxicity
Dipsacaceae
Drug resistance
Enzymes
Esters
Ethanol
Fatty acids
Flavonoids
Free radicals
Humans
Inflammation
Knautia
Lipoxygenase
Medicine, Traditional
Multidrug resistance
Phenolic acids
Phytosterols
Plant Extracts - chemistry
Quantitative analysis
Skin Diseases
Tumor necrosis factor-TNF
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Summary:The treatment of acne and other seborrheic diseases has arisen as a significant clinical challenge due to the increasing appearance of multi-drug resistant pathogens and a high frequency of recurrent lesions. Taking into consideration the fact that some species are valuable curatives in skin diseases in traditional medicine, we assumed that the thus far unstudied species and may be a source of active substances used in skin diseases. The purpose of this study was to evaluate the antioxidant, anti-inflammatory, antibacterial, and cytotoxic activities of their extracts and fractions. An LC-MS analysis revealed the presence of 47 compounds belonging to flavonoids and phenolic acids in both species while the GC-MS procedure allowed for the identification mainly sugar derivatives, phytosterols, and fatty acids and their esters. The ethanol as well as methanol-acetone-water (3:1:1) extracts of (KDE and KDM) exhibited great ability to scavenge free radicals and good capacity to inhibit cyclooxygenase-1, cyclooxygenase-2, and lipoxygenase. Moreover, they had the most favorable low minimal inhibitory concentration values against acne strains, and importantly, they were non-toxic toward normal skin fibroblasts. In conclusion, extracts seem to be promising and safe agents for further biomedical applications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24119188