Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study

( ) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children. We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, f...

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Published in:Healthcare (Basel) 2023-06, Vol.11 (11), p.1658
Main Authors: Nguyen, Tu Cam, Tang, Ngoc Le Chau, Le, Giao Kim Ngoc, Nguyen, Vy Thuy, Nguyen, Khuong Hoang Gia, Che, Thai Hoang, Phan, Van Thi Tuong, Nguyen, Ngoc Minh, Truong, Dinh Quang, Ngo, Xuan Minh, Nguyen, Hiep Thanh, Robert, Annie, Bontems, Patrick, Nguyen, Phuong Ngoc Van
Format: Article
Language:English
Subjects:
Age groups
Biopsy
Classification
Diagnostic tests
Disease
Endoscopy
Erythema
Histopathology
Hospitals
Infections
Nutritional status
Patients
Pediatrics
Population
Purpura
Regression analysis
Ulcers
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Summary:( ) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children. We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained. Among 336 enrolled children aged 4-16 (mean: 9.1 ± 2.4 years; 55.4% girls), infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. strains were detected at a higher rate in children with ulcers. Prevalence of and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of to reduce ulcer risk and gastric cancer later.
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare11111658