Recombinant mucin biotechnology and engineering

[Display omitted] Mucins represent a largely untapped class of polymeric building block for biomaterials, therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically encoded, sequence-specific mucins with defined physical and biochemical properties can be fabricated usin...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2023-02, Vol.193, p.114618-114618, Article 114618
Main Authors: Park, Sangwoo, Chin-Hun Kuo, Joe, Reesink, Heidi L., Paszek, Matthew J.
Format: Article
Language:English
Subjects:
Biomaterial
Biopolymer
Biotechnology
Drug delivery
Glycan
Humans
Lubrication
Mucin
Mucins - chemistry
Polysaccharides - chemistry
Recombinant
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Summary:[Display omitted] Mucins represent a largely untapped class of polymeric building block for biomaterials, therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically encoded, sequence-specific mucins with defined physical and biochemical properties can be fabricated using recombinant technologies. The pendent O-glycans of mucins are increasingly implicated in immunomodulation, suppression of pathogen virulence, and other biochemical activities. Recent advances in engineered cell production systems are enabling the scalable synthesis of recombinant mucins with precisely tuned glycan side chains, offering exciting possibilities to tune the biological functionality of mucin-based products. New metabolic and chemoenzymatic strategies enable further tuning and functionalization of mucin O-glycans, opening new possibilities to expand the chemical diversity and functionality of mucin building blocks. In this review, we discuss these advances, and the opportunities for engineered mucins in biomedical applications ranging from in vitro models to therapeutics.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2022.114618