Using Type I Collagen Gel to Prevent Postoperative Intrauterine Adhesion: A Multicenter Retrospective Study

We evaluated the clinical outcomes of using type 1 collagen gel after therapeutic resectoscopy; overall, 150 women aged > 20 who planned to undergo therapeutic resectoscopy were enrolled. The patients were randomly assigned to either of the anti-adhesive treatment groups: the type 1 collagen gel...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-05, Vol.12 (11), p.3764
Main Authors: Lee, Kwang Beom, Chon, Seung Joo, Kim, Sunghoon, Kim, Dae Yeon, Park, Chan Woo, Shin, So Jin, Kim, Seok Mo, Lee, Ki Hwan, Ji, Yong Il
Format: Article
Language:English
Subjects:
Abdomen
Abortion, Habitual
Adhesion
Adhesives
Biodegradable materials
Blood
Cell adhesion
Cellulose
Clinical medicine
Clinical trials
Collagen
Fibroblasts
Gynecology
Health aspects
Infertility
Patients
Physiology
Prevention
Risk factors
Surgery
Vagina
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Summary:We evaluated the clinical outcomes of using type 1 collagen gel after therapeutic resectoscopy; overall, 150 women aged > 20 who planned to undergo therapeutic resectoscopy were enrolled. The patients were randomly assigned to either of the anti-adhesive treatment groups: the type 1 collagen gel (Collabarrier ) (study group; N = 75) or the sodium hyaluronate and sodium carboxymethylcellulose gel group (control group; N = 75) after resectoscopy. One month after applying anti-adhesive materials, postoperative intrauterine adhesions were evaluated using second-look hysteroscopy; the incidence rate of postoperative intrauterine adhesions examined through second-look hysteroscopy showed no significant differences between the groups. There were no statistical differences between the frequency and mean scores of the type and intensity of adhesions in both groups. Finally, no significant differences in adverse events, serious adverse events, adverse device effects, and serious adverse device effects were noted between the two groups; type 1 collagen gel can be effectively and safely used in intrauterine surgery to minimize postoperative adhesions, thereby eventually decreasing the prevalence of infertility, secondary amenorrhea, and recurrent pregnancy loss in reproductive women.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12113764