Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

Biochemistry of bioluminescence of the marine parchment tubeworm has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from algae, which demonstrate bioluminesc...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (11), p.9466
Main Authors: Zagitova, Renata I, Purtov, Konstantin V, Shcheglov, Aleksandr S, Mineev, Konstantin S, Dubinnyi, Maxim A, Myasnyanko, Ivan N, Belozerova, Olga A, Pakhomova, Vera G, Petushkov, Valentin N, Rodionova, Natalia S, Lushpa, Vladislav A, Guglya, Elena B, Kovalchuk, Sergey, Kozhemyako, Valeri B, Mirza, Jeremy D, Oliveira, Anderson G, Yampolsky, Ilia V, Kaskova, Zinaida M, Tsarkova, Aleksandra S
Format: Article
Language:English
Subjects:
Algae
Animals
Bioluminescence
Biomass
Carbon
Chaetopterus
Chromatography
Communication
Enzymes
Fatty acids
Ferroptosis
Glycerol
Ions
Luciferases - chemistry
Luminescent Measurements
NMR
Nuclear magnetic resonance
Oxidation
Parchment
Peroxides
Polychaeta
Polyunsaturated fatty acids
Scientific imaging
Substrate specificity
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Summary:Biochemistry of bioluminescence of the marine parchment tubeworm has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from algae, which demonstrate bioluminescence activity with luciferase in the presence of Fe ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms24119466