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Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System
Biochemistry of bioluminescence of the marine parchment tubeworm has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from algae, which demonstrate bioluminesc...
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| Published in: | International journal of molecular sciences 2023-05, Vol.24 (11), p.9466 |
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| container_issue | 11 |
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| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Zagitova, Renata I Purtov, Konstantin V Shcheglov, Aleksandr S Mineev, Konstantin S Dubinnyi, Maxim A Myasnyanko, Ivan N Belozerova, Olga A Pakhomova, Vera G Petushkov, Valentin N Rodionova, Natalia S Lushpa, Vladislav A Guglya, Elena B Kovalchuk, Sergey Kozhemyako, Valeri B Mirza, Jeremy D Oliveira, Anderson G Yampolsky, Ilia V Kaskova, Zinaida M Tsarkova, Aleksandra S |
| description | Biochemistry of bioluminescence of the marine parchment tubeworm
has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from
algae, which demonstrate bioluminescence activity with
luciferase in the presence of Fe
ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase. |
| doi_str_mv | 10.3390/ijms24119466 |
| format | article |
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has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from
algae, which demonstrate bioluminescence activity with
luciferase in the presence of Fe
ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.</description><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24119466</identifier><identifier>PMID: 37298416</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Algae ; Animals ; Bioluminescence ; Biomass ; Carbon ; Chaetopterus ; Chromatography ; Communication ; Enzymes ; Fatty acids ; Ferroptosis ; Glycerol ; Ions ; Luciferases - chemistry ; Luminescent Measurements ; NMR ; Nuclear magnetic resonance ; Oxidation ; Parchment ; Peroxides ; Polychaeta ; Polyunsaturated fatty acids ; Scientific imaging ; Substrate specificity</subject><ispartof>International journal of molecular sciences, 2023-05, Vol.24 (11), p.9466</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9269-2160 ; 0000-0003-1752-0726 ; 0000-0002-2418-9421 ; 0000-0001-5065-1360 ; 0000-0002-5463-0169 ; 0000-0003-2433-8201 ; 0000-0001-6336-060X ; 0000-0002-5603-5371</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2824010203/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2824010203?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37298416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zagitova, Renata I</creatorcontrib><creatorcontrib>Purtov, Konstantin V</creatorcontrib><creatorcontrib>Shcheglov, Aleksandr S</creatorcontrib><creatorcontrib>Mineev, Konstantin S</creatorcontrib><creatorcontrib>Dubinnyi, Maxim A</creatorcontrib><creatorcontrib>Myasnyanko, Ivan N</creatorcontrib><creatorcontrib>Belozerova, Olga A</creatorcontrib><creatorcontrib>Pakhomova, Vera G</creatorcontrib><creatorcontrib>Petushkov, Valentin N</creatorcontrib><creatorcontrib>Rodionova, Natalia S</creatorcontrib><creatorcontrib>Lushpa, Vladislav A</creatorcontrib><creatorcontrib>Guglya, Elena B</creatorcontrib><creatorcontrib>Kovalchuk, Sergey</creatorcontrib><creatorcontrib>Kozhemyako, Valeri B</creatorcontrib><creatorcontrib>Mirza, Jeremy D</creatorcontrib><creatorcontrib>Oliveira, Anderson G</creatorcontrib><creatorcontrib>Yampolsky, Ilia V</creatorcontrib><creatorcontrib>Kaskova, Zinaida M</creatorcontrib><creatorcontrib>Tsarkova, Aleksandra S</creatorcontrib><title>Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Biochemistry of bioluminescence of the marine parchment tubeworm
has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from
algae, which demonstrate bioluminescence activity with
luciferase in the presence of Fe
ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.</description><subject>Algae</subject><subject>Animals</subject><subject>Bioluminescence</subject><subject>Biomass</subject><subject>Carbon</subject><subject>Chaetopterus</subject><subject>Chromatography</subject><subject>Communication</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Ferroptosis</subject><subject>Glycerol</subject><subject>Ions</subject><subject>Luciferases - chemistry</subject><subject>Luminescent Measurements</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxidation</subject><subject>Parchment</subject><subject>Peroxides</subject><subject>Polychaeta</subject><subject>Polyunsaturated fatty acids</subject><subject>Scientific imaging</subject><subject>Substrate specificity</subject><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkE1LxDAQhoMo7rp68ywBL16q-WqanGStnyAorHotaTvdzdI2a9OK--8Nuop6moF5eHjfQeiQklPONTmzy8YzQakWUm6hMRWMRYTIZDvsUtJIxlqO0J73S0IYZ7HeRSOeMK0ElWP0krp2OcxNDyW-tNA6W-BpYUv8CJ17tyV4bDyeDbnvuwB5bFucLgz0btVDN3h8YV09NLYFX0BbAJ6tfQ_NPtqpTO3hYDMn6Pn66im9je4fbu7S6X204pz3UU5zJSnLeU4TMFoypgpgSihCK9CxLrRhCc-JioukqqgQSWm0YjImRNMiBj5B51_e1ZA3UIYIIWadrTrbmG6dOWOzv5fWLrK5e8soYTHXlAXDycbQudcBfJ81NlSpa9OCG3zGFBNSKaVFQI__oUs3dG3o90mR4CQ8UEe_I_1k-f45_wATWoOz</recordid><startdate>20230530</startdate><enddate>20230530</enddate><creator>Zagitova, Renata I</creator><creator>Purtov, Konstantin V</creator><creator>Shcheglov, Aleksandr S</creator><creator>Mineev, Konstantin S</creator><creator>Dubinnyi, Maxim A</creator><creator>Myasnyanko, Ivan N</creator><creator>Belozerova, Olga A</creator><creator>Pakhomova, Vera G</creator><creator>Petushkov, Valentin N</creator><creator>Rodionova, Natalia S</creator><creator>Lushpa, Vladislav A</creator><creator>Guglya, Elena B</creator><creator>Kovalchuk, Sergey</creator><creator>Kozhemyako, Valeri B</creator><creator>Mirza, Jeremy D</creator><creator>Oliveira, Anderson G</creator><creator>Yampolsky, Ilia V</creator><creator>Kaskova, Zinaida M</creator><creator>Tsarkova, Aleksandra S</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9269-2160</orcidid><orcidid>https://orcid.org/0000-0003-1752-0726</orcidid><orcidid>https://orcid.org/0000-0002-2418-9421</orcidid><orcidid>https://orcid.org/0000-0001-5065-1360</orcidid><orcidid>https://orcid.org/0000-0002-5463-0169</orcidid><orcidid>https://orcid.org/0000-0003-2433-8201</orcidid><orcidid>https://orcid.org/0000-0001-6336-060X</orcidid><orcidid>https://orcid.org/0000-0002-5603-5371</orcidid></search><sort><creationdate>20230530</creationdate><title>Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System</title><author>Zagitova, Renata I ; Purtov, Konstantin V ; Shcheglov, Aleksandr S ; Mineev, Konstantin S ; Dubinnyi, Maxim A ; Myasnyanko, Ivan N ; Belozerova, Olga A ; Pakhomova, Vera G ; Petushkov, Valentin N ; Rodionova, Natalia S ; Lushpa, Vladislav A ; Guglya, Elena B ; Kovalchuk, Sergey ; Kozhemyako, Valeri B ; Mirza, Jeremy D ; Oliveira, Anderson G ; Yampolsky, Ilia V ; Kaskova, Zinaida M ; Tsarkova, Aleksandra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p333t-b1b8612b3b17ea96228ce284801fe959c9a273b085c7ff1447da982650091c5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algae</topic><topic>Animals</topic><topic>Bioluminescence</topic><topic>Biomass</topic><topic>Carbon</topic><topic>Chaetopterus</topic><topic>Chromatography</topic><topic>Communication</topic><topic>Enzymes</topic><topic>Fatty acids</topic><topic>Ferroptosis</topic><topic>Glycerol</topic><topic>Ions</topic><topic>Luciferases - 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algae, which demonstrate bioluminescence activity with
luciferase in the presence of Fe
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| ispartof | International journal of molecular sciences, 2023-05, Vol.24 (11), p.9466 |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Algae Animals Bioluminescence Biomass Carbon Chaetopterus Chromatography Communication Enzymes Fatty acids Ferroptosis Glycerol Ions Luciferases - chemistry Luminescent Measurements NMR Nuclear magnetic resonance Oxidation Parchment Peroxides Polychaeta Polyunsaturated fatty acids Scientific imaging Substrate specificity |
| title | Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System |
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