How to Develop Drug Delivery System Based on Carbohydrate Nanoparticles Targeted to Brain Tumors

• Published in: Polymers 2023-05, Vol.15 (11), p.2516
• Main Authors: Silant'ev, Vladimir E, Shmelev, Mikhail E, Belousov, Andrei S, Patlay, Aleksandra A, Shatilov, Roman A, Farniev, Vladislav M, Kumeiko, Vadim V
• Format: Article
• Language: English
• Subjects: Biocompatibility; Biodegradation; Biopolymers; Blood-brain barrier; Brain; Brain cancer; Brain tumors; Cancer; Cancer therapies; Carbohydrates; Cellulose; Chemotherapy; Cytotoxicity; Drug carriers; Drug delivery systems; Drugs; Gliomas; Hyaluronic acid; Metastasis; Nanomaterials; Nanoparticles; Nanotechnology; Pharmaceuticals; Review; Side effects; Tissue engineering; Toxicity; Tumors; Vehicles
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym15112516

Brain tumors are the most difficult to treat, not only because of the variety of their forms and the small number of effective chemotherapeutic agents capable of suppressing tumor cells, but also limited by poor drug transport across the blood-brain barrier (BBB). Nanoparticles are promising drug delivery solutions promoted by the expansion of nanotechnology, emerging in the creation and practical use of materials in the range from 1 to 500 nm. Carbohydrate-based nanoparticles is a unique platform for active molecular transport and targeted drug delivery, providing biocompatibility, biodegradability, and a reduction in toxic side effects. However, the design and fabrication of biopolymer colloidal nanomaterials have been and remain highly challenging to date. Our review is devoted to the description of carbohydrate nanoparticle synthesis and modification, with a brief overview of the biological and promising clinical outcomes. We also expect this manuscript to highlight the great potential of carbohydrate nanocarriers for drug delivery and targeted treatment of gliomas of various grades and glioblastomas, as the most aggressive of brain tumors.