Piroxicam and Doxepin—An Alternative to Narcotic Analgesics in Managing Advanced Cancer Pain

To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day). Of 30 patients presenting with severe pain of cancer of various origins, 7 continue...

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Bibliographic Details
Published in:The Western journal of medicine 1988-03, Vol.148 (3), p.303-306
Main Authors: Cohn, L., Machado, Antonio F., Bier, Robert, Cohn, Marthe
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Clinical Medicine
Doxepin - adverse effects
Doxepin - therapeutic use
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Neoplasms - physiopathology
Pain - drug therapy
Piroxicam - adverse effects
Piroxicam - therapeutic use
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Summary:To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day). Of 30 patients presenting with severe pain of cancer of various origins, 7 continued to death with piroxicam and doxepin therapy. An additional 17 were successfully treated for 6 to 66 weeks with therapy reported here but, as disease progressed, required supplemental narcotics. The remaining six abandoned the use of piroxicam due to complications of therapy, which ranged from diarrhea to gastric perforation; serious complications were associated with patients' failure to adhere to a prescribed regimen of sucralfate. Therapy with piroxicam and doxepin proved to be safe and efficacious.
ISSN:0093-0415
1476-2978