A closer look at the synapse: dlg1[4K] enables cell-specific visualization of PSD-95/DLG1

The PSD-95 homolog, DLG1, is important for excitatory synapse structure and function throughout the Drosophila nervous system. In this issue of Cell Reports Methods, Parisi et al. present a tool, dlg1[4K], that enables cell-specific DLG1 visualization without altering basal synaptic physiology. This...

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Bibliographic Details
Published in:Cell reports methods 2023-05, Vol.3 (5), p.100487, Article 100487
Main Authors: Hendricks, Emily L., Liebl, Faith L.W.
Format: Article
Language:English
Subjects:
Discs Large Homolog 1 Protein
Disks Large Homolog 4 Protein
Membrane Proteins - genetics
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Synapses - metabolism
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Summary:The PSD-95 homolog, DLG1, is important for excitatory synapse structure and function throughout the Drosophila nervous system. In this issue of Cell Reports Methods, Parisi et al. present a tool, dlg1[4K], that enables cell-specific DLG1 visualization without altering basal synaptic physiology. This tool will potentially enhance our understanding of neuronal development and function in both circuits and individual synapses. The PSD-95 homolog, DLG1, is important for excitatory synapse structure and function throughout the Drosophila nervous system. In this issue of Cell Reports Methods, Parisi et al. present a tool, dlg1[4K], that enables cell-specific DLG1 visualization without altering basal synaptic physiology. This tool will potentially enhance our understanding of neuronal development and function in both circuits and individual synapses.
ISSN:2667-2375
2667-2375
DOI:10.1016/j.crmeth.2023.100487