Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm

Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are p...

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Bibliographic Details
Published in:Neurology : neuroimmunology & neuroinflammation 2023-07, Vol.10 (4)
Main Authors: Tisavipat, Nanthaya, Chang, Bryce K, Ali, Farwa, Pittock, Sean J, Kammeyer, Ryan, Declusin, Anthony, Cohn, Samuel J, Flanagan, Eoin P
Format: Article
Language:English
Subjects:
Antibodies, Antinuclear
Clinical/Scientific Note
Diplopia
Dystonia - diagnosis
Dystonia - etiology
Humans
Laryngismus - complications
Laryngismus - diagnosis
Paraneoplastic Syndromes, Nervous System
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Summary:Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis.
ISSN:2332-7812
2332-7812
DOI:10.1212/NXI.0000000000200128