Urolithiasis in patients with inflammatory bowel disease: A systematic review and meta-analysis of 13,339,065 individuals

This study aimed to summarize the current literature regarding the prevalence of renal stones in patients with inflammatory bowel disease (IBD). Moreover, we aimed to evaluate the risk factors of urolithiasis in patients with IBD and the difference between patients with IBD and healthy controls in t...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2023-06, Vol.102 (24), p.e33938-e33938
Main Authors: Abdulrhman, Aldukhayel, Alsweed, Adil, Alotaibi, May Rashed, Aldakhil, Abdullah Yousef, Alahmadi, Shahad Fahad, Albishri, Saud Musallum, Alhmed, Nurah Ibrahem
Format: Article
Language:English
Subjects:
Colitis, Ulcerative - complications
Colitis, Ulcerative - epidemiology
Humans
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - epidemiology
Kidney Calculi - complications
Risk Factors
Systematic Review and Meta-Analysis
Urolithiasis - complications
Urolithiasis - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to summarize the current literature regarding the prevalence of renal stones in patients with inflammatory bowel disease (IBD). Moreover, we aimed to evaluate the risk factors of urolithiasis in patients with IBD and the difference between patients with IBD and healthy controls in terms of urinary profile. On February 23, 2022, a computerized search was conducted on PubMed, OVID via MEDLINE, Web of Science, and Scopus using relevant keywords. Three independent reviewers performed 2-stage screening and data extraction. The National Institutes of Health tools were employed for quality assessment. Review Manager 5.4 software was used to calculate the mean difference (MD) between IBD patients and non-IBD in terms of urine profile using the Inverse-variance model and to estimate the odds ratio of reported risk factors for renal stones with the Generic Inverse-Variance model. Thirty-two articles (n = 13,339,065 patients) were included. The overall prevalence of renal stones in patients with IBD was 6.3%, 95% Confidence interval (4.8%-8.3%). The prevalence of urolithiasis was more common in Chron's disease vs Ulcerative colitis (7.9% vs 5.6%) and in old studies (1964-2009) than in more recent studies (2010-2022) (7.3% vs 5.2%), respectively. Compared to non-IBD patients, patients with IBD were associated with significantly lower urine volume (MD = -518.84 mL/day, P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000033938