Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

Abstract Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone...

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Bibliographic Details
Published in:Open forum infectious diseases 2023-06, Vol.10 (6), p.ofad299-ofad299
Main Authors: Williams, Frank B, Kader, Md Abdul, Dickson, Dorothy M, Colgate, E Ross, Alam, Masud, Haque, Rashidul, Petri, William A, Kirkpatrick, Beth D, Lee, Benjamin
Format: Article
Language:English
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Brief Report
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Summary:Abstract Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad299