High miR-126-3p levels associated with cardiovascular events in a general population

•A renewed interest exists in miRNAs as biomarkers in cardiovascular disease.•miR-126–3p is associated with albuminuria, a marker of endothelial dysfunction, in hypertension.•High miR-126–3p levels are associated with cardiovascular events in general population. Endothelial dysfunction is a forerunn...

Full description

Saved in:
Bibliographic Details
Published in:European journal of internal medicine 2023-07, Vol.113, p.49-56
Main Authors: Martinez-Arroyo, Olga, Ortega, Ana, Flores-Chova, Ana, Sanchez-Garcia, Belen, Garcia-Garcia, Ana B, Chaves, Felipe J, Martin-Escudero, Juan C, Forner, Maria Jose, Redon, Josep, Cortes, Raquel
Format: Article
Language:English
Subjects:
Albuminuria
Biomarker
Biomarkers
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Cardiovascular event
Cardiovascular risk
Endothelial dysfunction
Humans
Hypertension - epidemiology
MicroRNA
MicroRNAs - genetics
Original
Retrospective Studies
Stroke
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•A renewed interest exists in miRNAs as biomarkers in cardiovascular disease.•miR-126–3p is associated with albuminuria, a marker of endothelial dysfunction, in hypertension.•High miR-126–3p levels are associated with cardiovascular events in general population. Endothelial dysfunction is a forerunner of atherosclerosis, leading to cardiovascular disease, and albuminuria is a marker of endothelial dysfunction. Circulating levels of microRNAs are emerging as potential biomarkers for cardiovascular disease. Here we estimate the predictive value of a plasma microRNAs signature associated with albuminuria in the incidence of cardiovascular events. Plasma microRNAs quantified in hypertensive patients by next generation sequencing were validated in a cohort of patients and controls by real-time quantitative PCR. The microRNAs found to be associated with albuminuria were analysed for their prognostic value in predicting cardiovascular events incidence on a retrospective, population-based study (Hortega Study), using Cox proportional hazard models. A plasma microRNA profile was identified in the discovery cohort (n = 48) associated with albuminuria and three microRNAs (miR-126–3p, miR-1260b and miR-374a-5p) were confirmed in the validation cohort (n = 98). The microRNA signature discriminates urinary albumin excretion at baseline (n = 1025), and predicts the incidence of cardiovascular events and coronary heart disease and stroke in a general population retrospective study within a 14-year follow-up (n = 926). High miR-126–3p levels were associated with a shorter time free of both cardiovascular events (HR=1.48, (1.36–1.62), p 
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2023.04.013