Depression and anxiety in colorectal cancer patients: Ties to pain, fatigue, and inflammation

Objective Colorectal cancer poses a significant threat to both psychological and physical health. This study examined relationships between anxiety and depressive symptoms with pain, fatigue, and inflammation among colorectal patients. Methods Colorectal cancer patients (n = 88, stages 0‐IV) complet...

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Published in:Psycho-oncology (Chichester, England) England), 2022-09, Vol.31 (9), p.1536-1544
Main Authors: Renna, Megan E., Shrout, M. Rosie, Madison, Annelise A., Alfano, Catherine M., Povoski, Stephen P., Lipari, Adele M., Carson, William E., Malarkey, William B., Kiecolt‐Glaser, Janice K.
Format: Article
Language:English
Subjects:
Anxiety
Anxiety - epidemiology
Anxiety - psychology
Blood tests
Body mass index
C-Reactive Protein - metabolism
Clinical significance
Colorectal cancer
Colorectal Neoplasms - psychology
depression
Depression - psychology
Fatigue
Fatigue - epidemiology
Fatigue - etiology
Fatigue - psychology
Female
Health psychology
Health status
Humans
Inflammation
Menopause
Mental depression
Mental health
Oncology
Pain
Side effects
Symptoms
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Summary:Objective Colorectal cancer poses a significant threat to both psychological and physical health. This study examined relationships between anxiety and depressive symptoms with pain, fatigue, and inflammation among colorectal patients. Methods Colorectal cancer patients (n = 88, stages 0‐IV) completed a laboratory‐based study visit before undergoing adjuvant cancer treatment. Patients completed questionnaires assessing depressive, anxiety, pain, and fatigue symptoms. A blood sample was also collected to measure c‐reactive protein (CRP). Analyses controlled for age, sex, cancer stage, body mass index (BMI), and menopause status. Results Multiple linear regression analyses showed colorectal patients with higher depressive and anxiety symptoms had greater pain, fatigue, and CRP (ps 16) and anxiety symptoms (BAI >16) also had clinically‐elevated levels of CRP (>3 mg/L) (ps = 0.02). Conclusion These results extend findings from other cancer subgroups showing heightened symptom burden among patients with depression and anxiety. They also highlight the detrimental role that elevated anxiety and depressive symptoms may play in the physical and biological side effects associated with colorectal cancer.
ISSN:1057-9249
1099-1611
DOI:10.1002/pon.5986