High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by multiplex-PCR

Human papillomavirus (HPV) infection is known to be the main cause of cervical cancer. This study aimed to determine the prevalence of high-risk HPV genotypes in smear specimens taken from women who had normal or abnormal cytology using a multiplex PCR method. The study included 270 women aged betwe...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2022-12, Vol.156 (6), p.786-791
Main Authors: Gorur, Levent, Dolanbay, Mehmet, Ozturk, Figen, Canoz, Ozlem, Donmez-Altuntas, Hamiyet
Format: Article
Language:English
Subjects:
Adult
Aged
Colposcopy
Female
Human Papillomavirus Viruses
Humans
Middle Aged
Multiplex Polymerase Chain Reaction
Papanicolaou Test
Papillomaviridae - genetics
Papillomavirus Infections - epidemiology
Papillomavirus Infections - genetics
Practice: Original article
Pregnancy
Uterine Cervical Neoplasms - pathology
Vaginal Smears
Young Adult
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Summary:Human papillomavirus (HPV) infection is known to be the main cause of cervical cancer. This study aimed to determine the prevalence of high-risk HPV genotypes in smear specimens taken from women who had normal or abnormal cytology using a multiplex PCR method. The study included 270 women aged between 19 and 69 yr with or without suspicious cervical abnormalities. A Pap smear sample from each patient was cytologically examined, and HPV typing was performed using a multiplex fluorescent PCR method. Those who were high-risk HPV positive and had a normal or abnormal cytology were further evaluated by colposcopy and biopsy. The total HPV positivity was 43 per cent (116/270). HPV positivity in the patients with an abnormal cytology was 77 per cent (33/43), whereas it was only 37 per cent (83/227) in women with normal cytology, which showed a significant difference (P
ISSN:0971-5916
0975-9174
DOI:10.4103/ijmr.IJMR_2335_20