Cerebrospinal fluid enolase in stroke

This study relates the level of alpha and gamma enolase in cerebrospinal fluid sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Twenty-eight patients were studied, two with transient ischaemic attacks and 26...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1984-07, Vol.47 (7), p.724-729
Main Authors: Hay, E, Royds, J A, Davies-Jones, G A, Lewtas, N A, Timperley, W R, Taylor, C B
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain - enzymology
Cerebral Infarction - enzymology
Female
Humans
Isoenzymes - cerebrospinal fluid
Male
Medical sciences
Middle Aged
Neurology
Phosphopyruvate Hydratase - cerebrospinal fluid
Prognosis
Radioimmunoassay
Vascular diseases and vascular malformations of the nervous system
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Summary:This study relates the level of alpha and gamma enolase in cerebrospinal fluid sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Twenty-eight patients were studied, two with transient ischaemic attacks and 26 with completed stroke due to infarction. The cerebrospinal fluid enolase was raised in the two patients with transient ischaemic attacks and 23 with completed stroke. There was a positive correlation between the volume of the infarct and the level of cerebrospinal fluid alpha and gamma enolase. A high cerebrospinal fluid enolase was always associated with a poor prognosis.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.47.7.724