The long term experience of thymectomy for myasthenia gravis

A retrospective survey of the records of 287 patients with generalised myasthenia gravis treated at New End Hospital and later at the Royal Free Hospital by anticholinesterase drugs, with or without thymectomy, between the years 1942 and 1976, shows that 62% of patients were improved. The timing of...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1985-05, Vol.48 (5), p.401-406
Main Authors: Scadding, G K, Havard, C W, Lange, M J, Domb, I
Format: Article
Language:English
Subjects:
Age Factors
Biological and medical sciences
Cholinesterase Inhibitors - therapeutic use
Combined Modality Therapy
Diseases of striated muscles. Neuromuscular diseases
Female
Humans
Male
Medical sciences
Myasthenia Gravis - complications
Myasthenia Gravis - therapy
Neurology
Retrospective Studies
Sex Factors
Thymectomy
Thymoma - complications
Thymoma - surgery
Thymus Neoplasms - complications
Thymus Neoplasms - surgery
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cited_by cdi_FETCH-LOGICAL-b510t-ca16af77e2b20b62061448becbc266370f741e9de494c66718f9aa2b27049d433
cites cdi_FETCH-LOGICAL-b510t-ca16af77e2b20b62061448becbc266370f741e9de494c66718f9aa2b27049d433
container_end_page 406
container_issue 5
container_start_page 401
container_title Journal of neurology, neurosurgery and psychiatry
container_volume 48
creator Scadding, G K
Havard, C W
Lange, M J
Domb, I
description A retrospective survey of the records of 287 patients with generalised myasthenia gravis treated at New End Hospital and later at the Royal Free Hospital by anticholinesterase drugs, with or without thymectomy, between the years 1942 and 1976, shows that 62% of patients were improved. The timing of the operation, the grading of disease and the age and sex of the patient did not greatly influence overall results. The poor diagnosis of thymic tumours was confirmed in this series. A decrease occurred in the number of patients achieving complete remission after 1961, although the proportion of patients improving did not fall. It is possible that anticholinesterase therapy may alter the response to thymectomy.
doi_str_mv 10.1136/jnnp.48.5.401
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The timing of the operation, the grading of disease and the age and sex of the patient did not greatly influence overall results. The poor diagnosis of thymic tumours was confirmed in this series. A decrease occurred in the number of patients achieving complete remission after 1961, although the proportion of patients improving did not fall. It is possible that anticholinesterase therapy may alter the response to thymectomy.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.48.5.401</identifier><identifier>PMID: 3998750</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Age Factors ; Biological and medical sciences ; Cholinesterase Inhibitors - therapeutic use ; Combined Modality Therapy ; Diseases of striated muscles. 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identifier ISSN: 0022-3050
ispartof Journal of neurology, neurosurgery and psychiatry, 1985-05, Vol.48 (5), p.401-406
issn 0022-3050
1468-330X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1028325
source Open Access: PubMed Central
subjects Age Factors
Biological and medical sciences
Cholinesterase Inhibitors - therapeutic use
Combined Modality Therapy
Diseases of striated muscles. Neuromuscular diseases
Female
Humans
Male
Medical sciences
Myasthenia Gravis - complications
Myasthenia Gravis - therapy
Neurology
Retrospective Studies
Sex Factors
Thymectomy
Thymoma - complications
Thymoma - surgery
Thymus Neoplasms - complications
Thymus Neoplasms - surgery
title The long term experience of thymectomy for myasthenia gravis
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