Comparative evaluation of metformin & sitaformin in classic PCOS patients undergoing intracytoplasmic sperm injection: A randomized controlled pilot study

Background & objectives: Studies have shown that insulin resistance and hyperinsulinaemia play a major role in the pathogenesis of polycystic ovary syndrome (PCOS). Therefore, the use of insulin sensitizing drugs in the treatment of PCOS has attracted the attention of medicine and researchers. T...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2023-01, Vol.157 (1), p.66-73
Main Authors: Modarres, Shahrzad, Daneshjou, Delbar, Mehranjani, Malek, Ali Shariatzadeh, Seyed
Format: Article
Language:English
Subjects:
Antidiabetics
Care and treatment
Complications and side effects
Dosage and administration
Embryos
Female
Humans
Hypoglycemic agents
Insulin
Insulin resistance
Male
Metformin - therapeutic use
Pilot Projects
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
Practice: Original
Prevention
Risk factors
Semen
Sperm
Sperm Injections, Intracytoplasmic
Stein-Leventhal syndrome
Citations: Items that this one cites
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Summary:Background & objectives: Studies have shown that insulin resistance and hyperinsulinaemia play a major role in the pathogenesis of polycystic ovary syndrome (PCOS). Therefore, the use of insulin sensitizing drugs in the treatment of PCOS has attracted the attention of medicine and researchers. The aim of this study was to investigate the effects of sitaformin (sitagliptin/metformin) and metformin on the quality of oocyte and embryo in classic PCOS patients undergoing intracytoplasmic sperm injection (ICSI). Methods: Sixty patients of PCOS (25-35 yr) were randomly allocated into three groups (n=20, each group): a metformin-treated group (administered metformin 500 mg twice daily), a sitaformin-treated group (administered sitaformin 50/500 mg twice daily) and a placebo group. Participants in all the groups received the drug two months prior to the start of the ovulation cycle and treatment continued until the day of the oocyte aspiration. Results: Serum insulin and total testosterone levels decreaseed significantly after treatment in both the treatment groups as compared to the placebo (P
ISSN:0971-5916
0975-9174
DOI:10.4103/ijmr.IJMR_2139_20