Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B

Objectives Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use o...

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Published in:Annals of nuclear medicine 2023-07, Vol.37 (7), p.410-418
Main Authors: Tada, Tomohiro, Hara, Kazuhiro, Fujita, Naotoshi, Ito, Yoshinori, Yamaguchi, Hiroshi, Ohdake, Reiko, Kawabata, Kazuya, Ogura, Aya, Kato, Toshiyasu, Yokoi, Takamasa, Masuda, Michihito, Abe, Shinji, Miyao, Shinichi, Naganawa, Shinji, Katsuno, Masahisa, Watanabe, Hirohisa, Sobue, Gen, Kato, Katsuhiko
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyloid
Cerebellum
Cognitive ability
Corpus callosum
Cortex
Emission analysis
Image processing
Imaging
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Neurodegenerative diseases
Neuroimaging
Nuclear Medicine
Original
Original Article
Pons
Positron emission
Positron emission tomography
Quantitative analysis
Radiology
Three dimensional analysis
Tomography
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Summary:Objectives Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using 11 C-PiB compared to the cerebellar cortex. Methods We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups. Results SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p 
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-023-01843-y