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Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B
Objectives Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use o...
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| Published in: | Annals of nuclear medicine 2023-07, Vol.37 (7), p.410-418 |
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| container_title | Annals of nuclear medicine |
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| creator | Tada, Tomohiro Hara, Kazuhiro Fujita, Naotoshi Ito, Yoshinori Yamaguchi, Hiroshi Ohdake, Reiko Kawabata, Kazuya Ogura, Aya Kato, Toshiyasu Yokoi, Takamasa Masuda, Michihito Abe, Shinji Miyao, Shinichi Naganawa, Shinji Katsuno, Masahisa Watanabe, Hirohisa Sobue, Gen Kato, Katsuhiko |
| description | Objectives
Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using
11
C-PiB compared to the cerebellar cortex.
Methods
We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups.
Results
SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p |
| doi_str_mv | 10.1007/s12149-023-01843-y |
| format | article |
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Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using
11
C-PiB compared to the cerebellar cortex.
Methods
We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups.
Results
SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p < 0.01).
Conclusions
Our data suggest that the pons and corpus callosum might be valid reference regions.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-023-01843-y</identifier><identifier>PMID: 37160863</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Alzheimer's disease ; Amyloid ; Cerebellum ; Cognitive ability ; Corpus callosum ; Cortex ; Emission analysis ; Image processing ; Imaging ; Magnetic resonance imaging ; Medical imaging ; Medicine ; Medicine & Public Health ; Neurodegenerative diseases ; Neuroimaging ; Nuclear Medicine ; Original ; Original Article ; Pons ; Positron emission ; Positron emission tomography ; Quantitative analysis ; Radiology ; Three dimensional analysis ; Tomography</subject><ispartof>Annals of nuclear medicine, 2023-07, Vol.37 (7), p.410-418</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b11d686defbfeb680ea5db87d756254fdab146e73d89081aa52c74d2062dc7d93</citedby><cites>FETCH-LOGICAL-c406t-b11d686defbfeb680ea5db87d756254fdab146e73d89081aa52c74d2062dc7d93</cites><orcidid>0000-0002-2083-9319</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Tada, Tomohiro</creatorcontrib><creatorcontrib>Hara, Kazuhiro</creatorcontrib><creatorcontrib>Fujita, Naotoshi</creatorcontrib><creatorcontrib>Ito, Yoshinori</creatorcontrib><creatorcontrib>Yamaguchi, Hiroshi</creatorcontrib><creatorcontrib>Ohdake, Reiko</creatorcontrib><creatorcontrib>Kawabata, Kazuya</creatorcontrib><creatorcontrib>Ogura, Aya</creatorcontrib><creatorcontrib>Kato, Toshiyasu</creatorcontrib><creatorcontrib>Yokoi, Takamasa</creatorcontrib><creatorcontrib>Masuda, Michihito</creatorcontrib><creatorcontrib>Abe, Shinji</creatorcontrib><creatorcontrib>Miyao, Shinichi</creatorcontrib><creatorcontrib>Naganawa, Shinji</creatorcontrib><creatorcontrib>Katsuno, Masahisa</creatorcontrib><creatorcontrib>Watanabe, Hirohisa</creatorcontrib><creatorcontrib>Sobue, Gen</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><title>Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>Objectives
Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using
11
C-PiB compared to the cerebellar cortex.
Methods
We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups.
Results
SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p < 0.01).
Conclusions
Our data suggest that the pons and corpus callosum might be valid reference regions.</description><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Cerebellum</subject><subject>Cognitive ability</subject><subject>Corpus callosum</subject><subject>Cortex</subject><subject>Emission analysis</subject><subject>Image processing</subject><subject>Imaging</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Nuclear Medicine</subject><subject>Original</subject><subject>Original Article</subject><subject>Pons</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Quantitative analysis</subject><subject>Radiology</subject><subject>Three dimensional analysis</subject><subject>Tomography</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kkuO1DAQhiMEYpqBC7CyxIZNwHbcjrNCQ4sBpJFgAWvLiSuJR4md8aM1zYprcKU5BifBmW6BYMHKJddfn-rxF8Vzgl8RjOvXgVDCmhLTqsREsKo8PCg2RHBWclZVD4sNbggrayLqs-JJCNcYU7EV9HFxVtWEY8GrTXG3c_OivIpmDwhu1Wxsjp1FrkdxBLQ4G5CyGnXOLymgTk2TC2lGKiAPPXiwHeRoMKuwdx7dJGWjiSfiXk3pCDQ2w4KJPscwmxDWz-hmN3i1jAdkZjUYO9wzLqZvI5gZ_M_vPwLSJoAKgFJY84Tsys8mxtAmP4xo7d8lq8u3T4tHvZoCPDu958XXy3dfdh_Kq0_vP-4ursqOYR7LlhDNBdfQtz20XGBQW92KWtdbTres16oljENdadFgQZTa0q5mmmJOdVfrpjov3hy5S2pn0B3Y6NUkF58n8AfplJF_Z6wZ5eD2kqz7x5hkwssTwbubBCHKvI8OpklZcClIKghpWD7QKn3xj_TaJW_zfFlFBcs3pSKr6FHVeRdCvsvvbgiWq1fk0Ssye0Xee0UeclF1LApZbAfwf9D_qfoFmu_Izw</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Tada, Tomohiro</creator><creator>Hara, Kazuhiro</creator><creator>Fujita, Naotoshi</creator><creator>Ito, Yoshinori</creator><creator>Yamaguchi, Hiroshi</creator><creator>Ohdake, Reiko</creator><creator>Kawabata, Kazuya</creator><creator>Ogura, Aya</creator><creator>Kato, Toshiyasu</creator><creator>Yokoi, Takamasa</creator><creator>Masuda, Michihito</creator><creator>Abe, Shinji</creator><creator>Miyao, Shinichi</creator><creator>Naganawa, Shinji</creator><creator>Katsuno, Masahisa</creator><creator>Watanabe, Hirohisa</creator><creator>Sobue, Gen</creator><creator>Kato, Katsuhiko</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2083-9319</orcidid></search><sort><creationdate>20230701</creationdate><title>Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B</title><author>Tada, Tomohiro ; Hara, Kazuhiro ; Fujita, Naotoshi ; Ito, Yoshinori ; Yamaguchi, Hiroshi ; Ohdake, Reiko ; Kawabata, Kazuya ; Ogura, Aya ; Kato, Toshiyasu ; Yokoi, Takamasa ; Masuda, Michihito ; Abe, Shinji ; Miyao, Shinichi ; Naganawa, Shinji ; Katsuno, Masahisa ; Watanabe, Hirohisa ; Sobue, Gen ; Kato, Katsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b11d686defbfeb680ea5db87d756254fdab146e73d89081aa52c74d2062dc7d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Cerebellum</topic><topic>Cognitive ability</topic><topic>Corpus callosum</topic><topic>Cortex</topic><topic>Emission analysis</topic><topic>Image processing</topic><topic>Imaging</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Nuclear Medicine</topic><topic>Original</topic><topic>Original Article</topic><topic>Pons</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Quantitative analysis</topic><topic>Radiology</topic><topic>Three dimensional analysis</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tada, Tomohiro</creatorcontrib><creatorcontrib>Hara, Kazuhiro</creatorcontrib><creatorcontrib>Fujita, Naotoshi</creatorcontrib><creatorcontrib>Ito, Yoshinori</creatorcontrib><creatorcontrib>Yamaguchi, Hiroshi</creatorcontrib><creatorcontrib>Ohdake, Reiko</creatorcontrib><creatorcontrib>Kawabata, Kazuya</creatorcontrib><creatorcontrib>Ogura, Aya</creatorcontrib><creatorcontrib>Kato, Toshiyasu</creatorcontrib><creatorcontrib>Yokoi, Takamasa</creatorcontrib><creatorcontrib>Masuda, Michihito</creatorcontrib><creatorcontrib>Abe, Shinji</creatorcontrib><creatorcontrib>Miyao, Shinichi</creatorcontrib><creatorcontrib>Naganawa, Shinji</creatorcontrib><creatorcontrib>Katsuno, Masahisa</creatorcontrib><creatorcontrib>Watanabe, Hirohisa</creatorcontrib><creatorcontrib>Sobue, Gen</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tada, Tomohiro</au><au>Hara, Kazuhiro</au><au>Fujita, Naotoshi</au><au>Ito, Yoshinori</au><au>Yamaguchi, Hiroshi</au><au>Ohdake, Reiko</au><au>Kawabata, Kazuya</au><au>Ogura, Aya</au><au>Kato, Toshiyasu</au><au>Yokoi, Takamasa</au><au>Masuda, Michihito</au><au>Abe, Shinji</au><au>Miyao, Shinichi</au><au>Naganawa, Shinji</au><au>Katsuno, Masahisa</au><au>Watanabe, Hirohisa</au><au>Sobue, Gen</au><au>Kato, Katsuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><date>2023-07-01</date><risdate>2023</risdate><volume>37</volume><issue>7</issue><spage>410</spage><epage>418</epage><pages>410-418</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objectives
Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using
11
C-PiB compared to the cerebellar cortex.
Methods
We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups.
Results
SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p < 0.01).
Conclusions
Our data suggest that the pons and corpus callosum might be valid reference regions.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>37160863</pmid><doi>10.1007/s12149-023-01843-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2083-9319</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature |
| subjects | Alzheimer's disease Amyloid Cerebellum Cognitive ability Corpus callosum Cortex Emission analysis Image processing Imaging Magnetic resonance imaging Medical imaging Medicine Medicine & Public Health Neurodegenerative diseases Neuroimaging Nuclear Medicine Original Original Article Pons Positron emission Positron emission tomography Quantitative analysis Radiology Three dimensional analysis Tomography |
| title | Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B |
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