The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication

Cervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of the spinal cord in cervical spine. These insid...

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Published in:Neurosurgical review 2023-06, Vol.46 (1), p.149-149, Article 149
Main Authors: Bonosi, Lapo, Musso, Sofia, Cusimano, Luigi Maria, Porzio, Massimiliano, Giovannini, Evier Andrea, Benigno, Umberto Emanuele, Giammalva, Giuseppe Roberto, Gerardi, Rosa Maria, Brunasso, Lara, Costanzo, Roberta, Paolini, Federica, Sciortino, Andrea, Campisi, Benedetta Maria, Giardina, Kevin, Scalia, Gianluca, Iacopino, Domenico Gerardo, Maugeri, Rosario
Format: Article
Language:English
Subjects:
Adult
Cervical Vertebrae - pathology
Cervical Vertebrae - surgery
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neuronal Plasticity
Neurosurgery
Prognosis
Review
Spinal Cord Diseases - surgery
Spinal Cord Injuries - pathology
Spinal Osteophytosis - diagnosis
Spinal Osteophytosis - pathology
Spondylosis - pathology
Spondylosis - surgery
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Summary:Cervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of the spinal cord in cervical spine. These insidious damage mechanisms can result in the reorganization of cortical and subcortical areas. The cerebral cortex can reorganize due to spinal cord injury and may play a role in preserving neurological function. To date, the gold standard treatment of cervical myelopathy is surgery, comprising anterior, posterior, and combined approaches. However, the complex physiologic recovery processes involving cortical and subcortical neural reorganization following surgery are still inadequately understood. It has been demonstrated that diffusion MRI and functional imaging and techniques, such as transcranial magnetic stimulation (TMS) or functional magnetic resonance imaging (fMRI), can provide new insights into the diagnosis and prognosis of CSM. This review aims to shed light on the state-of-the-art regarding the pattern of cortical and subcortical areas reorganization and recovery before and after surgery in CSM patients, underlighting the critical role of neuroplasticity.
ISSN:1437-2320
0344-5607
1437-2320
DOI:10.1007/s10143-023-02062-9