Immune-mediated necrotizing myopathy: Report of two cases

Immune-mediated necrotizing myopathy is a rare autoimmune myopathy characterized by muscle weakness and elevated serum creatine kinase, with unique skeletal muscle pathology and magnetic resonance imaging features. In this paper, two patients are reported: One was positive for anti-signal recognitio...

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Bibliographic Details
Published in:World journal of clinical cases 2023-05, Vol.11 (15), p.3552-3559
Main Authors: Chen, Bi-Hong, Zhu, Xue-Min, Xie, Lei, Hu, Huai-Qiang
Format: Article
Language:English
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Case Report
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Summary:Immune-mediated necrotizing myopathy is a rare autoimmune myopathy characterized by muscle weakness and elevated serum creatine kinase, with unique skeletal muscle pathology and magnetic resonance imaging features. In this paper, two patients are reported: One was positive for anti-signal recognition particle antibody, and the other was positive for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody. The clinical characteristics and treatment of the two patients were analysed, and the literature was reviewed to improve the recognition, diagnosis, and treatment of this disease.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v11.i15.3552