Resolution of hepatic abscess after interferon gamma in chronic granulomatous disease

• Published in: Archives of disease in childhood 1993-10, Vol.69 (4), p.443-445
• Main Authors: Hague, R A, Eastham, E J, Lee, R E, Cant, A J
• Format: Article
• Language: English
• Subjects: Abscesses; Antibiotics; Biological and medical sciences; C-reactive protein; Candidiasis - therapy; Child, Preschool; Chronic granulomatous disease; Erythrocyte sedimentation rate; Granulomatous Disease, Chronic - therapy; Humans; Immunomodulators; Interferon; Interferon-gamma - therapeutic use; Intravenous administration; Leukocyte Count; Liver - microbiology; Liver Abscess - diagnostic imaging; Liver Abscess - therapy; Liver diseases; Male; Medical sciences; Pediatrics; Pharmacology. Drug treatments; Recombinant Proteins; Tomography, X-Ray Computed
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.69.4.443

Recombinant interferon gamma has been used prophylactically in children with chronic granulomatous disease, but its role in the treatment of acute infective episodes has not been defined. A 3 year old boy presented with multiple candidal liver abscesses and was given intravenous antifungal treatment and he showed initial improvement. After six weeks his erythrocyte sedimentation rate and C reactive protein remained raised, and a computed tomogram showed a single abscess in the left lobe of the liver from which pus was drained and Staphylococcus aureus isolated. During the next eight months the abscess persisted despite appropriate intravenous antibiotics and percutaneous drainage. Subphrenic extension precluded definitive surgery. Nine months after initial presentation recombinant interferon gamma 0.05 mg/m2 intravenously was commenced three times a week. Complete resolution occurred within two months. It is concluded that interferon gamma is useful in treating infective episodes, and further study of the use of prophylactic antimicrobial treatment and intermittent interferon gamma during acute episodes is now required.