Resolution of hepatic abscess after interferon gamma in chronic granulomatous disease

Recombinant interferon gamma has been used prophylactically in children with chronic granulomatous disease, but its role in the treatment of acute infective episodes has not been defined. A 3 year old boy presented with multiple candidal liver abscesses and was given intravenous antifungal treatment...

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Published in:Archives of disease in childhood 1993-10, Vol.69 (4), p.443-445
Main Authors: Hague, R A, Eastham, E J, Lee, R E, Cant, A J
Format: Article
Language:English
Subjects:
Abscesses
Antibiotics
Biological and medical sciences
C-reactive protein
Candidiasis - therapy
Child, Preschool
Chronic granulomatous disease
Erythrocyte sedimentation rate
Granulomatous Disease, Chronic - therapy
Humans
Immunomodulators
Interferon
Interferon-gamma - therapeutic use
Intravenous administration
Leukocyte Count
Liver - microbiology
Liver Abscess - diagnostic imaging
Liver Abscess - therapy
Liver diseases
Male
Medical sciences
Pediatrics
Pharmacology. Drug treatments
Recombinant Proteins
Tomography, X-Ray Computed
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description Recombinant interferon gamma has been used prophylactically in children with chronic granulomatous disease, but its role in the treatment of acute infective episodes has not been defined. A 3 year old boy presented with multiple candidal liver abscesses and was given intravenous antifungal treatment and he showed initial improvement. After six weeks his erythrocyte sedimentation rate and C reactive protein remained raised, and a computed tomogram showed a single abscess in the left lobe of the liver from which pus was drained and Staphylococcus aureus isolated. During the next eight months the abscess persisted despite appropriate intravenous antibiotics and percutaneous drainage. Subphrenic extension precluded definitive surgery. Nine months after initial presentation recombinant interferon gamma 0.05 mg/m2 intravenously was commenced three times a week. Complete resolution occurred within two months. It is concluded that interferon gamma is useful in treating infective episodes, and further study of the use of prophylactic antimicrobial treatment and intermittent interferon gamma during acute episodes is now required.
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A 3 year old boy presented with multiple candidal liver abscesses and was given intravenous antifungal treatment and he showed initial improvement. After six weeks his erythrocyte sedimentation rate and C reactive protein remained raised, and a computed tomogram showed a single abscess in the left lobe of the liver from which pus was drained and Staphylococcus aureus isolated. During the next eight months the abscess persisted despite appropriate intravenous antibiotics and percutaneous drainage. Subphrenic extension precluded definitive surgery. Nine months after initial presentation recombinant interferon gamma 0.05 mg/m2 intravenously was commenced three times a week. Complete resolution occurred within two months. 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A 3 year old boy presented with multiple candidal liver abscesses and was given intravenous antifungal treatment and he showed initial improvement. After six weeks his erythrocyte sedimentation rate and C reactive protein remained raised, and a computed tomogram showed a single abscess in the left lobe of the liver from which pus was drained and Staphylococcus aureus isolated. During the next eight months the abscess persisted despite appropriate intravenous antibiotics and percutaneous drainage. Subphrenic extension precluded definitive surgery. Nine months after initial presentation recombinant interferon gamma 0.05 mg/m2 intravenously was commenced three times a week. Complete resolution occurred within two months. 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subjects Abscesses
Antibiotics
Biological and medical sciences
C-reactive protein
Candidiasis - therapy
Child, Preschool
Chronic granulomatous disease
Erythrocyte sedimentation rate
Granulomatous Disease, Chronic - therapy
Humans
Immunomodulators
Interferon
Interferon-gamma - therapeutic use
Intravenous administration
Leukocyte Count
Liver - microbiology
Liver Abscess - diagnostic imaging
Liver Abscess - therapy
Liver diseases
Male
Medical sciences
Pediatrics
Pharmacology. Drug treatments
Recombinant Proteins
Tomography, X-Ray Computed
title Resolution of hepatic abscess after interferon gamma in chronic granulomatous disease
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