Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets

Ovarian cancer (OC) is the eighth cancer both in prevalence and mortality in women and represents the deadliest female reproductive cancer. Due to generally vague symptoms, OC is frequently diagnosed only at a late and advanced stage, resulting in high mortality. The tumor extracellular matrix and c...

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Bibliographic Details
Published in:Cancers 2023-06, Vol.15 (12), p.3125
Main Authors: Oto, Julia, Le, Quang-Khoi, Schäfer, Sebastian D, Kiesel, Ludwig, Marí-Alexandre, Josep, Gilabert-Estellés, Juan, Medina, Pilar, Götte, Martin
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Cancer
Cancer patients
Cell growth
Development and progression
Diagnosis
Drug development
Drug discovery
Extracellular matrix
Gene expression
Glycoproteins
Health aspects
Heparan sulfate
Heparan sulfate proteoglycans
Kinases
Medical prognosis
Membrane proteins
Metastasis
Mortality
Ovarian cancer
Pathogenesis
Prognosis
Proteins
Review
Sulfates
Syndecan
Therapeutic targets
Tumors
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Summary:Ovarian cancer (OC) is the eighth cancer both in prevalence and mortality in women and represents the deadliest female reproductive cancer. Due to generally vague symptoms, OC is frequently diagnosed only at a late and advanced stage, resulting in high mortality. The tumor extracellular matrix and cellular matrix receptors play a key role in the pathogenesis of tumor progression. Syndecans are a family of four transmembrane heparan sulfate proteoglycans (PG), including syndecan-1, -2, -3, and -4, which are dysregulated in a myriad of cancers, including OC. Many clinicopathological studies suggest that these proteins are promising diagnostic and prognostic biomarkers for OC. Furthermore, functions of the syndecan family in the regulation of cellular processes make it an interesting pharmacological target for anticancer therapies.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15123125