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Targeted Therapies and Developing Precision Medicine in Gastric Cancer

Gastric cancer is an aggressive disease with survival remaining poor in the advanced setting. More than a decade after the first targeted treatment was approved, still only HER2, MSI and PDL-1 status have reached everyday practice in terms of guiding treatment options for these patients. However, va...

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Bibliographic Details
Published in:Cancers 2023-06, Vol.15 (12), p.3248
Main Authors: Pihlak, Rille, Fong, Caroline, Starling, Naureen
Format: Article
Language:English
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Summary:Gastric cancer is an aggressive disease with survival remaining poor in the advanced setting. More than a decade after the first targeted treatment was approved, still only HER2, MSI and PDL-1 status have reached everyday practice in terms of guiding treatment options for these patients. However, various new targets and novel treatments have recently been investigated and have shown promise in improving survival outcomes. In this review, we will summarise previous and currently ongoing studies on predictive biomarkers, possible new targeted treatments, potential reasons for conflicting trial results and hope for the future of precision medicine in gastric cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15123248