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Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia
Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cr...
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| Published in: | Archives of disease in childhood 1994-04, Vol.70 (4), p.275-280 |
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| container_end_page | 280 |
| container_issue | 4 |
| container_start_page | 275 |
| container_title | Archives of disease in childhood |
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| creator | Christie, D Battin, M Leiper, A D Chessells, J Vargha-Khadem, F Neville, B G |
| description | Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cranial radiotherapy. All children had mild/soft neurological signs, mostly of coordination. None had a major motor disability. All but the youngest child had cataracts; two children required an operation for these. All children were growth hormone deficient. Verbal IQ, attention, and concentration were selectively reduced (with respect to normative levels). The time between the two treatments, age at relapse, and higher doses of radiotherapy all correlated with cognitive outcome, with girls showing greater impairments than boys. Only two children were performing at age appropriate levels on measures of academic achievement. It is concluded that neurological and neuropsychological morbidity is significantly increased by the current treatments prescribed after the relapse of leukaemia. |
| doi_str_mv | 10.1136/adc.70.4.275 |
| format | article |
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Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cranial radiotherapy. All children had mild/soft neurological signs, mostly of coordination. None had a major motor disability. All but the youngest child had cataracts; two children required an operation for these. All children were growth hormone deficient. Verbal IQ, attention, and concentration were selectively reduced (with respect to normative levels). The time between the two treatments, age at relapse, and higher doses of radiotherapy all correlated with cognitive outcome, with girls showing greater impairments than boys. Only two children were performing at age appropriate levels on measures of academic achievement. It is concluded that neurological and neuropsychological morbidity is significantly increased by the current treatments prescribed after the relapse of leukaemia.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.70.4.275</identifier><identifier>PMID: 7514391</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age Factors ; Biological and medical sciences ; Bone marrow ; Bone marrow transplantation ; Brain - pathology ; Cataracts ; Child ; Child, Preschool ; Children ; Cognition Disorders - etiology ; Cranial Irradiation ; Developmental Disabilities - etiology ; Education ; Female ; Growth Disorders - etiology ; Growth hormones ; Hematologic and hematopoietic diseases ; Humans ; Infant ; Intelligence ; Irradiation ; Leukemia ; Leukemia, Lymphoid - pathology ; Leukemia, Lymphoid - radiotherapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukemic Infiltration - radiotherapy ; Male ; Medical sciences ; Methotrexate - adverse effects ; Morbidity ; Nervous System Diseases - etiology ; Neuropsychology ; Pediatrics ; Radiation Injuries - etiology ; Radiation therapy ; Radiotherapy - adverse effects ; Recurrence ; Remission ; Skull ; Whole-Body Irradiation</subject><ispartof>Archives of disease in childhood, 1994-04, Vol.70 (4), p.275-280</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Apr 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-dcf33488a2a79fcc56fe343fb8276011535baa155e24d0023e749c69eaf1c4113</citedby><cites>FETCH-LOGICAL-b506t-dcf33488a2a79fcc56fe343fb8276011535baa155e24d0023e749c69eaf1c4113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3079544982/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3079544982?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21378,21394,27924,27925,33611,33877,43733,43880,53791,53793,74221,74397</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4092727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7514391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christie, D</creatorcontrib><creatorcontrib>Battin, M</creatorcontrib><creatorcontrib>Leiper, A D</creatorcontrib><creatorcontrib>Chessells, J</creatorcontrib><creatorcontrib>Vargha-Khadem, F</creatorcontrib><creatorcontrib>Neville, B G</creatorcontrib><title>Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cranial radiotherapy. All children had mild/soft neurological signs, mostly of coordination. None had a major motor disability. All but the youngest child had cataracts; two children required an operation for these. All children were growth hormone deficient. Verbal IQ, attention, and concentration were selectively reduced (with respect to normative levels). The time between the two treatments, age at relapse, and higher doses of radiotherapy all correlated with cognitive outcome, with girls showing greater impairments than boys. Only two children were performing at age appropriate levels on measures of academic achievement. It is concluded that neurological and neuropsychological morbidity is significantly increased by the current treatments prescribed after the relapse of leukaemia.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Brain - pathology</subject><subject>Cataracts</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cognition Disorders - etiology</subject><subject>Cranial Irradiation</subject><subject>Developmental Disabilities - etiology</subject><subject>Education</subject><subject>Female</subject><subject>Growth Disorders - etiology</subject><subject>Growth hormones</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Intelligence</subject><subject>Irradiation</subject><subject>Leukemia</subject><subject>Leukemia, Lymphoid - pathology</subject><subject>Leukemia, Lymphoid - radiotherapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukemic Infiltration - radiotherapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - adverse effects</subject><subject>Morbidity</subject><subject>Nervous System Diseases - etiology</subject><subject>Neuropsychology</subject><subject>Pediatrics</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Recurrence</subject><subject>Remission</subject><subject>Skull</subject><subject>Whole-Body Irradiation</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNp9kd1rFDEUxYModa2--SoMKPjSWfM5SV4E2WorlApSRXwJdzJJd7YzkzGZEfe_b5Zdl_riU-CeHyfn3oPQS4KXhLDqHTR2KfGSL6kUj9CC8EqVFHP-GC0wxqzUSqmn6FlKG4wJVYqdoBMpCGeaLNDNtZtjGNPWrkMXblsLXQFDUwy78d9BmCcbeleAn1wsoutgTK4Ivui2_bgOdQdpam3RufkOXN_Cc_TEQ5fci8N7ir59-nizuiyvvlx8Xn24KmuBq6lsrGeMKwUUpPbWiso7xpmvFZUVJkQwUQMQIRzlDcaUOcm1rbQDTyzPu5-i93vfca5711g3TBE6M8a2h7g1AVrzrzK0a3MbfhuCqZZSZoPXB4MYfs0uTWYT5jjkzIZhqQXnWtFMne0pG0NK0fnjDwSbXQUmV2AkNtzkCjL-6mGqI3y4edbfHHRI-bo-wmDbdMQ41lTSXbZyj7Vpcn-OMsQ7U0kmhbn-vjLnP8_5j0vBzdfMv93zdb_5f8B7cD-sJw</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Christie, D</creator><creator>Battin, M</creator><creator>Leiper, A D</creator><creator>Chessells, J</creator><creator>Vargha-Khadem, F</creator><creator>Neville, B G</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19940401</creationdate><title>Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia</title><author>Christie, D ; Battin, M ; Leiper, A D ; Chessells, J ; Vargha-Khadem, F ; Neville, B G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-dcf33488a2a79fcc56fe343fb8276011535baa155e24d0023e749c69eaf1c4113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Brain - pathology</topic><topic>Cataracts</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cognition Disorders - etiology</topic><topic>Cranial Irradiation</topic><topic>Developmental Disabilities - etiology</topic><topic>Education</topic><topic>Female</topic><topic>Growth Disorders - etiology</topic><topic>Growth hormones</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Intelligence</topic><topic>Irradiation</topic><topic>Leukemia</topic><topic>Leukemia, Lymphoid - pathology</topic><topic>Leukemia, Lymphoid - radiotherapy</topic><topic>Leukemias. 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Myelofibrosis</topic><topic>Leukemic Infiltration - radiotherapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methotrexate - adverse effects</topic><topic>Morbidity</topic><topic>Nervous System Diseases - etiology</topic><topic>Neuropsychology</topic><topic>Pediatrics</topic><topic>Radiation Injuries - etiology</topic><topic>Radiation therapy</topic><topic>Radiotherapy - adverse effects</topic><topic>Recurrence</topic><topic>Remission</topic><topic>Skull</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christie, D</creatorcontrib><creatorcontrib>Battin, M</creatorcontrib><creatorcontrib>Leiper, A D</creatorcontrib><creatorcontrib>Chessells, J</creatorcontrib><creatorcontrib>Vargha-Khadem, F</creatorcontrib><creatorcontrib>Neville, B G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christie, D</au><au>Battin, M</au><au>Leiper, A D</au><au>Chessells, J</au><au>Vargha-Khadem, F</au><au>Neville, B G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>70</volume><issue>4</issue><spage>275</spage><epage>280</epage><pages>275-280</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cranial radiotherapy. All children had mild/soft neurological signs, mostly of coordination. None had a major motor disability. All but the youngest child had cataracts; two children required an operation for these. All children were growth hormone deficient. Verbal IQ, attention, and concentration were selectively reduced (with respect to normative levels). The time between the two treatments, age at relapse, and higher doses of radiotherapy all correlated with cognitive outcome, with girls showing greater impairments than boys. Only two children were performing at age appropriate levels on measures of academic achievement. It is concluded that neurological and neuropsychological morbidity is significantly increased by the current treatments prescribed after the relapse of leukaemia.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>7514391</pmid><doi>10.1136/adc.70.4.275</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1994-04, Vol.70 (4), p.275-280 |
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| subjects | Age Factors Biological and medical sciences Bone marrow Bone marrow transplantation Brain - pathology Cataracts Child Child, Preschool Children Cognition Disorders - etiology Cranial Irradiation Developmental Disabilities - etiology Education Female Growth Disorders - etiology Growth hormones Hematologic and hematopoietic diseases Humans Infant Intelligence Irradiation Leukemia Leukemia, Lymphoid - pathology Leukemia, Lymphoid - radiotherapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukemic Infiltration - radiotherapy Male Medical sciences Methotrexate - adverse effects Morbidity Nervous System Diseases - etiology Neuropsychology Pediatrics Radiation Injuries - etiology Radiation therapy Radiotherapy - adverse effects Recurrence Remission Skull Whole-Body Irradiation |
| title | Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia |
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