Inherited Reticulate Pigmentary Disorders

Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH), reticulate acropigmentation of...

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Bibliographic Details
Published in:Genes 2023-06, Vol.14 (6), p.1300
Main Authors: Lin, Min-Huei, Chou, Pei-Chen, Lee, I-Chen, Yang, Syuan-Fei, Yu, Hsin-Su, Yu, Sebastian
Format: Article
Language:English
Subjects:
Chromosomes
Dyskeratosis
Genetic aspects
Genetic diversity
Humans
Hyperpigmentation - genetics
Hyperpigmentation - pathology
Mutation
Pigmentation
Review
Search engines
Search strategies
Skin
Skin diseases
Skin Diseases, Genetic - genetics
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Summary:Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH), reticulate acropigmentation of Kitamura (RAK), Dowling-Degos disease (DDD), dyskeratosis congenita (DKC), Naegeli-Franceschetti-Jadassohn syndrome (NFJS), dermatopathia pigmentosa reticularis (DPR), and X-linked reticulate pigmentary disorder. Although reticulate pattern of pigmentation is a common characteristic of this spectrum of disorders, the distribution of pigmentation varies among these disorders, and there may be clinical manifestations beyond pigmentation. DSH, DUH, and RAK are mostly reported in East Asian ethnicities. DDD is more common in Caucasians, although it is also reported in Asian countries. Other RPDs show no racial predilection. This article reviews the clinical, histological, and genetic variations of inherited RPDs.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes14061300