Mastocytosis and Skin Cancer: The Current State of Knowledge

Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-06, Vol.24 (12), p.9840
Main Authors: Kaszuba, Agnieszka, Sławińska, Martyna, Żółkiewicz, Jakub, Sobjanek, Michał, Nowicki, Roman J, Lange, Magdalena
Format: Article
Language:English
Subjects:
Cancer therapies
Case reports
Cell proliferation
Cytokines
Development and progression
Disease
Epidemiology
Iatrogenesis
Kinases
Lung cancer
Mast cell disease
Mast cells
Mastocytosis
Medical research
Medicine, Experimental
Melanoma
Mutation
Review
Skin cancer
Tumors
Ultraviolet radiation
Urticaria
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Summary:Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this has not yet been clearly identified. In the literature, the potential influence of several factors has been suggested, including genetic background, the role of cytokines produced by mast cells, iatrogenic and hormonal factors. The article summarizes the current state of knowledge regarding the epidemiology, pathogenesis, diagnosis, and management of skin neoplasia in mastocytosis patients.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24129840