The Incidence of IgG4-Related and Inflammatory Abdominal Aortic Aneurysm Is Rare in a 101 Patient Cohort

Abdominal aortic aneurysms (AAA) are the most frequent aortic dilation, with considerable morbidity and mortality. Inflammatory (infl) and IgG4-positive AAAs represent specific subtypes of unclear incidence and clinical significance. Here, histologic and serologic analyses with retrospective clinica...

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Published in:Journal of clinical medicine 2023-06, Vol.12 (12), p.4029
Main Authors: Nackenhorst, Maja Carina, Kapalla, Marvin, Weidle, Simon, Kirchhoff, Felix, Zschäpitz, David, Sieber, Sabine, Reeps, Christian, Eckstein, Hans-Henning, Schneider, Heike, Thaler, Markus, Moog, Philipp, Busch, Albert, Sachs, Nadja
Format: Article
Language:English
Subjects:
Abdominal aneurysm
Antibodies
Aortic aneurysms
Cardiovascular disease
Chronic obstructive pulmonary disease
Clinical medicine
Clinical outcomes
Diagnosis
Health aspects
Histology
Hospitals
Immunoglobulin G
Inflammation
Ischemia
Laboratories
Leukocytes
Measurement
Mortality
Open source software
Patients
Risk factors
Statistics
Vein & artery diseases
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Summary:Abdominal aortic aneurysms (AAA) are the most frequent aortic dilation, with considerable morbidity and mortality. Inflammatory (infl) and IgG4-positive AAAs represent specific subtypes of unclear incidence and clinical significance. Here, histologic and serologic analyses with retrospective clinical data acquisition are investigated via detailed histology, including morphologic (HE, EvG: inflammatory subtype, angiogenesis, and fibrosis) and immunhistochemic analyses (IgG and IgG4). In addition, complement factors C3/C4 and immunoglobulins IgG, IgG2, IgG4 and IgE were measured in serum samples and clinical data uses patients' metrics, as well as through semi-automated morphometric analysis (diameter, volume, angulation and vessel tortuosity). A total of 101 eligible patients showed five (5%) IgG4 positive (all scored 1) and seven (7%) inflammatory AAAs. An increased degree of inflammation was seen in IgG4 positive and inflAAA, respectively. However, serologic analysis revealed no increased levels of IgG or IgG4. The operative procedure time was not different for those cases and the short-term clinical outcomes were equal for the entire AAA cohort. Overall, the incidence of inflammatory and IgG4-positive AAA samples seems very low based on histologic and serum analyses. Both entities must be considered distinct disease phenotypes. Short-term operative outcomes were not different for both sub-cohorts.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12124029