Rapid diagnosis of glucocorticoid suppressible hyperaldosteronism in infants and adolescents

Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detectio...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 1994-07, Vol.71 (1), p.40-43
Main Authors: Jamieson, A, Inglis, G C, Campbell, M, Fraser, R, Connell, J M
Format: Article
Language:English
Subjects:
Adolescent
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adult
Autoradiography
Base Sequence
Biological and medical sciences
Child
Child, Preschool
Crossing Over, Genetic
Cytochrome P-450 CYP11B2
Cytochrome P-450 Enzyme System - genetics
Endocrinopathies
Female
Genetic screening
Genotype
Glucocorticoids
Glucocorticoids - therapeutic use
Humans
Hyperaldosteronism - diagnosis
Hyperaldosteronism - drug therapy
Hyperaldosteronism - genetics
Hypertension
Infant, Newborn
Infants
Male
Medical diagnosis
Medical sciences
Molecular Sequence Data
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pediatrics
Pedigree
Polymorphism, Restriction Fragment Length
Steroid 11-beta-Hydroxylase - genetics
Teenagers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and children with GSH before the development of hypertension, allowing prompt treatment of hypertension if it occurs, and an opportunity to study the effects of growth and environmental influences on the progression of the condition.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.71.1.40