Comparative Study of Different Acupoints for Treating Acute Myocardial Ischemia in Mice

Acupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection from myocardial injury. We aimed to compare the effects among...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular translational research 2023-06, Vol.16 (3), p.644-661
Main Authors: Hong, Hao, Cao, Xin, Meng, Xiang-Min, Pang, Qiu-Yu, Zhu, Li-Juan, Yu, Shu-Guang, Zhu, Bing-Mei
Format: Article
Language:English
Subjects:
Acupuncture Points
Animals
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Disease Models, Animal
Human Genetics
Medicine
Medicine & Public Health
Mice
Myocardial Infarction - therapy
Myocardial Ischemia - therapy
Original
Original Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection from myocardial injury. We aimed to compare the effects among these three acupoints on the acute myocardial infarction mice model and to explore possible mechanisms for the first time. We found that PC6 is the most appropriate acupoint to deliver efficacy and safety to treat acute MI in mice. BL15 stimulation improved the systolic function, but increased the risk of arrhythmia. ST36 only slightly attenuated systolic function and had no effect on arrhythmia during MI. RNA profiles of skin tissue in local acupoints demonstrated that the most altered DEGs and related pathways may partly support its best effects of PC6 treatment on MI injury, and support the observed phenomenon of the acupoint specificity. Graphical abstract
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-022-10346-6