Maternal High-Fat Diet Controls Offspring Kidney Health and Disease

A balanced diet during gestation is critical for fetal development, and excessive intake of saturated fats during gestation and lactation is related to an increased risk of offspring kidney disease. Emerging evidence indicates that a maternal high-fat diet influences kidney health and disease of the...

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Bibliographic Details
Published in:Nutrients 2023-06, Vol.15 (12), p.2698
Main Authors: Liu, Hsi-Yun, Lee, Chen-Hao, Hsu, Chien-Ning, Tain, You-Lin
Format: Article
Language:English
Subjects:
Animal models
Breastfeeding & lactation
Carbon
Cholesterol
Diet
Fatty acids
Fetus
Fetuses
Gestation
Glycerol
Growth
Health risks
High density lipoprotein
High fat diet
Hypertension
Intestinal microflora
Kidney diseases
Kidneys
Lactation
Lipids
Lipoproteins
Metabolism
Molecular modelling
Nutrition
Offspring
Oils & fats
Physiology
Polyunsaturated fatty acids
Pregnancy
Public health
Review
Trans fats
Triglycerides
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Summary:A balanced diet during gestation is critical for fetal development, and excessive intake of saturated fats during gestation and lactation is related to an increased risk of offspring kidney disease. Emerging evidence indicates that a maternal high-fat diet influences kidney health and disease of the offspring via so-called renal programming. This review summarizes preclinical research documenting the connection between a maternal high-fat diet during gestation and lactation and offspring kidney disease, as well as the molecular mechanisms behind renal programming, and early-life interventions to offset adverse programming processes. Animal models indicate that offspring kidney health can be improved via perinatal polyunsaturated fatty acid supplementation, gut microbiota changes, and modulation of nutrient-sensing signals. These findings reinforce the significance of a balanced maternal diet for the kidney health of offspring.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15122698