A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes

Abstract Purpose Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polyp...

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Published in:The journal of clinical endocrinology and metabolism 2023-05, Vol.108 (5), p.e120-e128
Main Authors: Hart, Phil A, Kudva, Yogish C, Yadav, Dhiraj, Andersen, Dana K, Li, Yisheng, Toledo, Frederico G S, Wang, Fuchenchu, Bellin, Melena D, Bradley, David, Brand, Randall E, Cusi, Kenneth, Fisher, William, Mather, Kieren, Park, Walter G, Saeed, Zeb, Considine, Robert V, Graham, Sarah C, Rinaudo, Jo Ann, Serrano, Jose, Goodarzi, Mark O
Format: Article
Language:English
Subjects:
Adenocarcinoma
Body mass index
Carcinoma, Pancreatic Ductal - complications
Clinical
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Fasting
Humans
Pancreatic cancer
Pancreatic diseases
Pancreatic Neoplasms
Pancreatic Neoplasms - complications
Pancreatic Polypeptide
Pancreatitis
Pancreatitis, Chronic - complications
Polypeptides
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Summary:Abstract Purpose Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM). Methods Subjects with new-onset DM (
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgac670