They shall not grow mold: Soldiers of innate and adaptive immunity to fungi

Fungi are ubiquitous commensals, seasoned predators, and important agents of emerging infectious diseases [ 1 ]. The immune system assumes the essential responsibility for responding intelligently to the presence of known and novel fungi to maintain host health. In this Review, we describe the immun...

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Bibliographic Details
Published in:Seminars in immunology 2023-01, Vol.65, p.101673-101673, Article 101673
Main Authors: Woodring, Therese, Deepe, George S., Levitz, Stuart M., Wuethrich, Marcel, Klein, Bruce S.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Fungi
Humans
Immunity, Innate
Military Personnel
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Summary:Fungi are ubiquitous commensals, seasoned predators, and important agents of emerging infectious diseases [ 1 ]. The immune system assumes the essential responsibility for responding intelligently to the presence of known and novel fungi to maintain host health. In this Review, we describe the immune responses to pathogenic fungi and the varied array of fungal agents confronting the vertebrate host within the broader context of fungal and animal evolution. We provide an overview of the mechanistic details of innate and adaptive antifungal immune responses, as well as ways in which these basic mechanisms support the development of vaccines and immunotherapies.
ISSN:1044-5323
1096-3618
1096-3618
DOI:10.1016/j.smim.2022.101673