Steering CAR T cell epigenetic programs by tweaking manufacturing protocol

CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.1 demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process. CAR T cell persistence remains a signi...

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Bibliographic Details
Published in:Cell reports. Medicine 2023-06, Vol.4 (6), p.101080, Article 101080
Main Authors: Dukes, Meghan W., Krenciute, Giedre
Format: Article
Language:English
Subjects:
Brain Neoplasms - genetics
Epigenesis, Genetic
Humans
Immunotherapy, Adoptive - methods
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Receptors, Chimeric Antigen - metabolism
T-Lymphocytes - metabolism
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Summary:CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.1 demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process. CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.1 demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process.
ISSN:2666-3791
2666-3791
DOI:10.1016/j.xcrm.2023.101080