StrainNet: Improved Myocardial Strain Analysis of Cine MRI by Deep Learning from DENSE

• Published in: Radiology. Cardiothoracic imaging 2023-06, Vol.5 (3), p.e220196
• Main Authors: Wang, Yu, Sun, Changyu, Ghadimi, Sona, Auger, Daniel C, Croisille, Pierre, Viallon, Magalie, Mangion, Kenneth, Berry, Colin, Haggerty, Christopher M, Jing, Linyuan, Fornwalt, Brandon K, Cao, J Jane, Cheng, Joshua, Scott, Andrew D, Ferreira, Pedro F, Oshinski, John N, Ennis, Daniel B, Bilchick, Kenneth C, Epstein, Frederick H
• Format: Article
• Language: English
• Subjects: Original Research
• ISSN: 2638-6135; 2638-6135
• DOI: 10.1148/ryct.220196

To develop a three-dimensional (two dimensions + time) convolutional neural network trained with displacement encoding with stimulated echoes (DENSE) data for displacement and strain analysis of cine MRI. In this retrospective multicenter study, a deep learning model (StrainNet) was developed to predict intramyocardial displacement from contour motion. Patients with various heart diseases and healthy controls underwent cardiac MRI examinations with DENSE between August 2008 and January 2022. Network training inputs were a time series of myocardial contours from DENSE magnitude images, and ground truth data were DENSE displacement measurements. Model performance was evaluated using pixelwise end-point error (EPE). For testing, StrainNet was applied to contour motion from cine MRI. Global and segmental circumferential strain (E ) derived from commercial feature tracking (FT), StrainNet, and DENSE (reference) were compared using intraclass correlation coefficients (ICCs), Pearson correlations, Bland-Altman analyses, paired tests, and linear mixed-effects models. The study included 161 patients (110 men; mean age, 61 years ± 14 [SD]), 99 healthy adults (44 men; mean age, 35 years ± 15), and 45 healthy children and adolescents (21 males; mean age, 12 years ± 3). StrainNet showed good agreement with DENSE for intramyocardial displacement, with an average EPE of 0.75 mm ± 0.35. The ICCs between StrainNet and DENSE and FT and DENSE were 0.87 and 0.72, respectively, for global E and 0.75 and 0.48, respectively, for segmental E . Bland-Altman analysis showed that StrainNet had better agreement than FT with DENSE for global and segmental E . StrainNet outperformed FT for global and segmental E analysis of cine MRI. Image Postprocessing, MR Imaging, Cardiac, Heart, Pediatrics, Technical Aspects, Technology Assessment, Strain, Deep Learning, DENSE © RSNA, 2023.