Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

• Published in: Bone marrow transplantation (Basingstoke) 2022-07, Vol.57 (7), p.1150-1163
• Main Authors: Phelan, Rachel, Im, Annie, Hunter, Rebecca L., Inamoto, Yoshihiro, Lupo-Stanghellini, Maria Teresa, Rovo, Alicia, Badawy, Sherif M., Burns, Linda, Eissa, Hesham, Murthy, Hemant S., Prasad, Pinki, Sharma, Akshay, Suelzer, Elizabeth, Agrawal, Vaibhav, Aljurf, Mahmoud, Baker, Karen, Basak, Grzegorz W., Buchbinder, David, DeFilipp, Zachariah, Grkovic, Lana Desnica, Dias, Ajoy, Einsele, Hermann, Eisenberg, Michael L., Epperla, Narendranath, Farhadfar, Nosha, Flatau, Arthur, Gale, Robert Peter, Greinix, Hildegard, Hamilton, Betty K., Hashmi, Shahrukh, Hematti, Peiman, Jamani, Kareem, Maharaj, Dipnarine, Murray, John, Naik, Seema, Nathan, Sunita, Pavletic, Steven, Peric, Zinaida, Pulanic, Drazen, Ross, Richard, Salonia, Andrea, Sanchez-Ortega, Isabel, Savani, Bipin N., Schechter, Tal, Shah, Ami J., Smith, Stephanie M., Snowden, John A., Steinberg, Amir, Tremblay, Douglas, Vij, Sarah C., Walker, Lauren, Wolff, Daniel, Yared, Jean A., Schoemans, Hélène, Tichelli, André
• Format: Article
• Language: English
• Subjects: 42/100; 631/532/1542; 692/699/67/71; Adult; Blood; Bone Marrow; Cardiovascular disease; Cell Biology; Clinical medicine; Complications; Disease Progression; Erectile dysfunction; Graft versus host disease; Graft vs Host Disease - etiology; Graft-versus-host reaction; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Hypogonadism; Infertility; Internal Medicine; Keywords; Male; Males; Medical personnel; Medicine; Medicine & Public Health; Morbidity; Penis; Physicians; Public Health; Quality of Life; Reviews; Risk analysis; Risk factors; Sexual behavior; Sexual health; Stem cell transplantation; Stem Cells; Systematic review; Transplant Recipients; Transplantation
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/s41409-022-01591-z

Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.