The use of proteomics for the identification of promising vaccine and diagnostic biomarkers in Plasmodium falciparum

Plasmodium falciparum is the main cause of severe malaria in humans that can lead to death. There is growing evidence of drug-resistance in P. falciparum treatment, and the design of effective vaccines remains an ongoing strategy to control the disease. On the other hand, the recognition of specific...

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Bibliographic Details
Published in:Parasitology 2020-10, Vol.147 (12), p.1255-1262
Main Authors: Mansouri, Reza, Ali-Hassanzadeh, Mohammad, Shafiei, Reza, Savardashtaki, Amir, Karimazar, Mohammadreza, Anvari, Enayat, Nguewa, Paul, Rashidi, Sajad
Format: Article
Language:English
Subjects:
Animals
Antimalarials - pharmacology
Biomarkers - metabolism
Drug Resistance - genetics
Erythrocytes - parasitology
Genes, Protozoan
Humans
Life Cycle Stages - immunology
Malaria Vaccines - immunology
Malaria, Falciparum - diagnosis
Malaria, Falciparum - drug therapy
Malaria, Falciparum - immunology
Plasmodium falciparum - genetics
Plasmodium falciparum - immunology
Plasmodium falciparum - metabolism
Proteome - immunology
Proteome - metabolism
Proteomics - methods
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Review
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Summary:Plasmodium falciparum is the main cause of severe malaria in humans that can lead to death. There is growing evidence of drug-resistance in P. falciparum treatment, and the design of effective vaccines remains an ongoing strategy to control the disease. On the other hand, the recognition of specific diagnostic markers for P. falciparum can accelerate the diagnosis of this parasite in the early stages of infection. Therefore, the identification of novel antigenic proteins especially by proteomic tools is urgent for vaccination and diagnosis of P. falciparum. The proteome diversity of the life cycle stages of P. falciparum, the altered proteome of P. falciparum-infected human sera and altered proteins in P. falciparum-infected erythrocytes could be proposed as appropriate proteins for the aforementioned aims. Accordingly, this review highlights and proposes different proteins identified using proteomic approaches as promising markers in the diagnosis and vaccination of P. falciparum. It seems that most of the candidates identified in this study were able to elicit immune responses in the P. falciparum-infected hosts and they also played major roles in the life cycle, pathogenicity and key pathways of this parasite.
ISSN:0031-1820
1469-8161
DOI:10.1017/S003118202000102X