Generalised peripheral nerve dysfunction in acromegaly: a study by conventional and novel neurophysiological techniques

Twenty four patients with clinical, radiological and biochemical evidence of acromegaly were investigated by a number of independent neurophysiological tests. Two-thirds of the patients showed evidence of generalised peripheral nerve dysfunction. A significant correlation was found between total exc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1987-07, Vol.50 (7), p.886-894
Main Authors: Jamal, G A, Kerr, D J, McLellan, A R, Weir, A I, Davies, D L
Format: Article
Language:English
Subjects:
Acromegaly - complications
Acromegaly - physiopathology
Adult
Aged
Biological and medical sciences
Carpal Tunnel Syndrome - etiology
Carpal Tunnel Syndrome - physiopathology
Endocrinopathies
Female
Hot Temperature
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Male
Medical sciences
Middle Aged
Motor Neurons - physiopathology
Neural Conduction
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - physiopathology
Reaction Time
Sensory Thresholds
Vibration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Twenty four patients with clinical, radiological and biochemical evidence of acromegaly were investigated by a number of independent neurophysiological tests. Two-thirds of the patients showed evidence of generalised peripheral nerve dysfunction. A significant correlation was found between total exchangeable body sodium, an indicator of disease activity, and the severity of the neuropathy. The generalised peripheral nerve abnormality was found to occur independently of the associated carbohydrate intolerance human growth hormone levels and other endocrinological dysfunction in this disorder.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.50.7.886