Peripheral neuropathy associated with mycosis fungoides

A 56 year old man with acute sensory-motor polyneuropathy associated with mycosis fungoides is described. EMG studies showed diffuse signs of muscle denervation. A skin biopsy specimen showed a lymphocyte infiltration in the dermis, composed of mycosis cells characterised by deep invaginations of th...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1989-04, Vol.52 (4), p.536-538
Main Authors: Comola, M, Nemni, R, Comi, G, Corbo, M, Taccagni, G, Besana, C, Canal, N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Mycosis Fungoides - pathology
Nerve Degeneration
Nerve Fibers, Myelinated - pathology
Polyneuropathies - pathology
Skin - pathology
Skin Neoplasms - pathology
Sural Nerve - pathology
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Summary:A 56 year old man with acute sensory-motor polyneuropathy associated with mycosis fungoides is described. EMG studies showed diffuse signs of muscle denervation. A skin biopsy specimen showed a lymphocyte infiltration in the dermis, composed of mycosis cells characterised by deep invaginations of the nuclear membrane, and small Pautrier's microabscesses in the epidermis. Sural nerve biopsy revealed endoneurial fibrosis, a decreased number of myelinated fibres and acute axonal degeneration.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.52.4.536