The Aging–Cancer Cycle: Mechanisms and Opportunities for Intervention

Abstract Aging is the largest risk factor for the development of cancer. A growing body of literature indicates that aging and cancer often play a somewhat reciprocal relationship at various times. On the one hand, aging is a “driver” of cancer, and on the other, cancer is a “disease driver” of agin...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-07, Vol.78 (7), p.1234-1238
Main Authors: Sedrak, Mina S, Cohen, Harvey Jay
Format: Article
Language:English
Subjects:
Aged
Aging
Cancer
Cancer therapies
Cellular Senescence
Forecasting
Humans
Neoplasms - prevention & control
Older people
Risk Factors
Senescence
THE JOURNAL OF GERONTOLOGY: Medical Sciences
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Summary:Abstract Aging is the largest risk factor for the development of cancer. A growing body of literature indicates that aging and cancer often play a somewhat reciprocal relationship at various times. On the one hand, aging is a “driver” of cancer, and on the other, cancer is a “disease driver” of aging. Here, we synthesize our reflections on the current literature linking cancer and aging, with an eye on fundamental aging processes, such as cellular senescence. Additionally, we consider how interventions that target fundamental aging processes can potentially transform cancer care, from preventing cancer development and progression to reducing the burden of accelerated aging in cancer survivors. Finally, we conclude with a reflection highlighting our vision for future directions to advance the science of cancer and aging and its applicability to improve the care of older adults with cancer.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glac247