Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology

Mueller-matrix polarimetry is a powerful method allowing for the visualization of malformations in biological tissues and quantitative evaluation of alterations associated with the progression of various diseases. This approach, in fact, is limited in observation of spatial localization and scale-se...

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Bibliographic Details
Published in:Journal of biomedical optics 2023-10, Vol.28 (10), p.102903-102903
Main Authors: Sdobnov, Anton, Ushenko, Volodymir A., Trifonyuk, Liliya, Bakun, Oksana, Garazdyuk, Marta, Soltys, Irina V., Dubolazov, Olexander, Ushenko, Olexander G., Ushenko, Yuriy A., Bykov, Alexander, Meglinski, Igor
Format: Article
Language:English
Subjects:
Anisotropy
Birefringence
Humans
Male
Neoplasms
Optical Imaging - methods
Special Section on Polarimetry in Biomedical Optics, Part 1
Spectrum Analysis
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Summary:Mueller-matrix polarimetry is a powerful method allowing for the visualization of malformations in biological tissues and quantitative evaluation of alterations associated with the progression of various diseases. This approach, in fact, is limited in observation of spatial localization and scale-selective changes in the poly-crystalline compound of tissue samples. We aimed to improve the Mueller-matrix polarimetry approach by implementing the wavelet decomposition accompanied with the polarization-singular processing for express differential diagnosis of local changes in the poly-crystalline structure of tissue samples with various pathology. Mueller-matrix maps obtained experimentally in transmitted mode are processed utilizing a combination of a topological singular polarization approach and scale-selective wavelet analysis for quantitative assessment of the adenoma and carcinoma histological sections of the prostate tissues. A relationship between the characteristic values of the Mueller-matrix elements and singular states of linear and circular polarization is established within the framework of the phase anisotropy phenomenological model in terms of linear birefringence. A robust method for expedited (up to ) polarimetric-based differential diagnosis of local variations in the poly-crystalline structure of tissue samples containing various pathology abnormalities is introduced. The benign and malignant states of the prostate tissue are identified and assessed quantitatively with a superior accuracy provided by the developed Mueller-matrix polarimetry approach.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.28.10.102903