Comparison of two donor‐derived cell‐free DNA tests and a blood gene‐expression profile test in heart transplantation

Background Donor‐derived cell‐free DNA (dd‐cfDNA) testing is an emerging screening modality for noninvasive detection of acute rejection (AR). This study compared the testing accuracy for AR of two commercially available dd‐cfDNA and gene‐expression profiling (GEP) testing in heart transplant (HTx)...

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Bibliographic Details
Published in:Clinical transplantation 2023-06, Vol.37 (6), p.e14984-n/a
Main Authors: Rodgers, Nicholas, Gerding, Bryn, Cusi, Vincenzo, Vaida, Florin, Tada, Yuko, Morris, Gerald P., Adler, Eric D., Stehlik, Josef, Kim, Paul J.
Format: Article
Language:English
Subjects:
acute cellular rejection
acute rejection
antibody mediated rejection
biomarker
Biomarkers
Cell-Free Nucleic Acids - genetics
cell‐free DNA
dd‐cfDNA
endomyocardial biopsy
gene expression profiling
Graft Rejection - etiology
Graft Rejection - genetics
heart transplant
Heart Transplantation
Humans
Prospective Studies
Tissue Donors
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Summary:Background Donor‐derived cell‐free DNA (dd‐cfDNA) testing is an emerging screening modality for noninvasive detection of acute rejection (AR). This study compared the testing accuracy for AR of two commercially available dd‐cfDNA and gene‐expression profiling (GEP) testing in heart transplant (HTx) recipients. Methods This is a retrospective, observational study of HTx only patients who underwent standard and expanded single nucleotide polymorphism (SNP) dd‐cfDNA between October 2020 to January 2022. Comparison with GEP was also performed. Assays were compared for correlation, accurate classification, and prediction for AR. Results A total of 428 samples from 112 unique HTx patients were used for the study. A positive standard SNP correlated with the expanded SNP assay (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14984