Age-associated changes in electroretinography measures in companion dogs

• Published in: Documenta ophthalmologica 2023-08, Vol.147 (1), p.15-28
• Main Authors: Salzman, Michele M., Merten, Natascha, Panek, Wojciech K., Fefer, Gilad, Mondino, Alejandra, Westermeyer, Hans D., Gruen, Margaret E., Olby, Natasha J., Mowat, Freya M.
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Anesthesia; Animal breeding; Animals; Anxiolytics; Body weight; Child; Cross-Sectional Studies; Dark Adaptation; Dogs; Electroretinograms; Electroretinography; Humans; Medicine; Medicine & Public Health; Ophthalmology; Original Research Article; Pets; Photic Stimulation
• ISSN: 0012-4486; 1573-2622; 1573-2622
• DOI: 10.1007/s10633-023-09938-7

Purpose To determine the association between age and retinal full-field electroretinographic (ERG) measures in companion (pet) dogs, an important translational model species for human neurologic aging. Methods Healthy adult dogs with no significant ophthalmic abnormalities were included. Unilateral full-field light- and dark-adapted electroretinography was performed using a handheld device, with mydriasis and topical anaesthesia. Partial least squares effect screening analysis was performed to determine the effect of age, sex, body weight and use of anxiolytic medication on log-transformed ERG peak times and amplitudes; age and anxiolytic usage had significant effects on multiple ERG outcomes. Mixed model analysis was performed on data from dogs not receiving anxiolytic medications. Results In dogs not receiving anxiolytics, median age was 118 months (interquartile range 72–140 months, n = 77, 44 purebred, 33 mixed breed dogs). Age was significantly associated with prolonged peak times of a-waves (dark-adapted 3 and 10 cds/m 2 flash p