The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study

This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa). In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biopsy with and with...

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Published in:Ultrasonography 2023-07, Vol.42 (3), p.400-409
Main Authors: Jeon, Seong Soo, Kim, Chan Kyo, Park, Sung Yoon, Chung, Jae Hoon, Kang, Minyong, Sung, Hyun Hwan, Jeong, Byong Chang
Format: Article
Language:English
Subjects:
Biopsy
Magnetic resonance imaging
Original
Prostate cancer
prostatic neoplasms
Radiation
shear wave elastography
Software
Ultrasonic imaging
ultrasound
young’s modulus
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Summary:This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa). In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biopsy with and without a targeted biopsy. Tissue stiffness on SWE was measured in the target lesion and in 12 regions of the systematic biopsies, and the maximum (Emax), mean (Emean), and minimum (Emin) values of stiffness were generated. The area under the receiver operating characteristic curve (AUROC) for predicting clinically significant cancer (CSC) was calculated. Interobserver reliability and variability were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman plots, respectively. PCa was found in 78 of 488 regions (16%) in 17 patients. In region-based and patientbased analyses, the Emax, Emean, and Emin values of PCa were significantly higher than those of benign prostate tissue (P
ISSN:2288-5919
2288-5943
DOI:10.14366/usg.22202