Neuroleptic-induced Parkinson's syndrome: clinical features and results of treatment with levodopa

Twenty six consecutive patients with neuroleptic-induced Parkinson's syndrome (NIPS) are described. Their median age was 61 years, 60% were female, and most had received chronic neuroleptic medication for psychiatric indications. The clinical features were indistinguishable from idiopathic Park...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1988-06, Vol.51 (6), p.850-854
Main Authors: Hardie, R J, Lees, A J
Format: Article
Language:English
Subjects:
Adult
Aged
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Benserazide - therapeutic use
Biological and medical sciences
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Female
Humans
Levodopa - therapeutic use
Male
Medical sciences
Middle Aged
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - drug therapy
Pharmacology. Drug treatments
Psychotic Disorders - drug therapy
Toxicity: nervous system and muscle
Trihexyphenidyl - therapeutic use
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Summary:Twenty six consecutive patients with neuroleptic-induced Parkinson's syndrome (NIPS) are described. Their median age was 61 years, 60% were female, and most had received chronic neuroleptic medication for psychiatric indications. The clinical features were indistinguishable from idiopathic Parkinson's disease, except for the presence of co-existing orofacial chorea, limb dyskinesia or akathisia which provided an aetiological clue in 11 cases. Complete resolution of NIPS occurred in only two patients, one of whom later developed Parkinson's disease. Sixteen patients were treated with 300-1000 mg levodopa/benserazide for up to 4 years with few adverse effects but therapeutic response was disappointing.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.51.6.850