Calcineurin Inhibitor-Induced Type IV Renal Tubular Acidosis in Post-Bone Marrow Transplant: Review of Pathophysiology and Principles of Management

Calcineurin inhibitors (CNI) are the mainstay of immunosuppressant medications in both bone marrow transplants and solid organ transplants. Nephrotoxicity is a well-known adverse effect of this group. Type IV renal tubular acidosis is a potentially under-recognized complication. Here we report a cas...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-06, Vol.15 (6), p.e40215
Main Authors: Al-Omairi, Anwar, Abdulnasser Obaid, Mohammed, Agrawal, Indira, Abdalla, Amr, Al Rawas, Abdul Hakim
Format: Article
Language:English
Subjects:
Abdomen
Acidosis
Bone marrow
Case reports
Creatinine
Cytokines
Diet
Hematology
Hyperkalemia
Kidneys
Lymphocytes
Metabolism
Nephrology
Pathophysiology
Pediatrics
Pneumonia
Potassium
Sodium
Stem cell transplantation
T cell receptors
Urine
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Summary:Calcineurin inhibitors (CNI) are the mainstay of immunosuppressant medications in both bone marrow transplants and solid organ transplants. Nephrotoxicity is a well-known adverse effect of this group. Type IV renal tubular acidosis is a potentially under-recognized complication. Here we report a case of Omenn syndrome in a patient who underwent a bone marrow transplant and developed type IV renal tubular acidosis while on treatment with cyclosporine.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.40215